Related Publications

 

534	A. B. Smith, III and B. S. Freeze. (+)-Discodermalide: Total Syntheses, Construction of Novel Analogues, and Biological Evaluation: An Overview. Tetrahedron, 2008, 64, 261-298.
529	S. Shaw, H. Menzella, D. C. Myles, M. Xian, and A. B. Smith, III. Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product-a further simplification of the lactone region. Organic & Biomolecular Chemistry. 2007, 5, 2753-2755.
516	S. Xian, C. Kenesky, P. V Rucker, A. B. Smith, III, G. A. Orr, and S. B. Horwitz. A Photoaffinity Analogue of Discodermolide Specifically Labels a Peptide in -Tubulin. Biochemistry. 2006, 45, 11762-11775.
504	G. S. Hung, L. Lopez-Barcons, R. Perez-Soler, B. S. Freeze, A. B. Snith, III, G. L. Goldberg, S. B. Horowitz, and H. McDaid. Potentiation of Taxol Efficacy by Discodermolide in Ovarian Carcinoma Xenograft-bearing Mice. Clin. Cancer Res. 2006, 12, 298-304.
500	S. Mani, H. Huang, S. Sandarababu, W. Liu, G. Kalpana, A. B. Smith, III, and S. B. Horowitz. Activation of the Steriod and Xenobiotic Receptor (hPXR or SXR) by Non-Taxane Microtubule Stabilizing Agents. Clin. Cancer Res. 2005, 11, 6359-6369.
499	Smith, Amos B., III; Xian, Ming. Design, Synthesis, and Biological Evaluation of Simplified Analogues of (+)-Discodermolide. Additional Insights on the Importance of the Diene, the C(7) Hydroxyl, and the Lactone. Organic Letters (2005), 7(23), 5229-5232.
497	Smith, Amos B., III; Rucker, Paul V.; Brouard, Ignacio; Freeze, B. Scott; Xia, Shujun; Horwitz, Susan Band. Design, Synthesis, and Biological Evaluation of Potent Discodermolide Fluorescent and Photoaffinity Molecular Probes. Organic Letters (2005), 7(23), 5199-5202.
494	Smith, Amos B., III; Xian, Ming; Liu, Fenghua. Design, Total Synthesis, and Evaluation of C(13)-C(14) Cyclopropane Analogues of (+)-Discodermolide. Organic Letters (2005), 7(21), 4613-4616.
487	Smith, Amos B., III; Freeze, B. Scott; LaMarche, Matthew J.; Sager, Jason; Kinzler, Kenneth W.; Vogelstein, Bert. Discodermolide analogues as the chemical component of combination bacteriolytic therapy. Bioorganic & Medicinal Chemistry Letters (2005), 15(15), 3623-3626.
482	Klein Laura E; Freeze B Scott; Smith Amos B 3rd; Horwitz Susan Band The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell cycle (Georgetown, Tex.) (2005), 4(3), 501-7.
479	Shaw, Simon J.; Sundermann, Kurt F.; Burlingame, Mark A.; Myles, David C.; Freeze, B. Scott; Xian, Ming; Brouard, Ignacio; Smith, Amos B., III. Toward Understanding How the Lactone Moiety of Discodermolide Affects Activity. Journal of the American Chemical Society (2005), 127(18), 6532-6533.
478	Smith, Amos B., III; Freeze, B. Scott; Xian, Ming; Hirose, Tomoyasu. Total Synthesis of (+)-Discodermolide: A Highly Convergent Fourth-Generation Approach. Organic Letters (2005), 7(9), 1825-1828.
474	Smith, Amos B., III; Freeze, B. Scott; LaMarche, Matthew J.; Hirose, Tomoyasu; Brouard, Ignacio; Rucker, Paul V.; Xian, Ming; Sundermann, Kurt F.; Shaw, Simon J.; Burlingame, Mark A.; Horwitz, Susan Band; Myles, David C. Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide. Organic Letters (2005), 7(2), 311-314.
473	Smith, Amos B., III; Rucker, Paul V.; Brouard, Ignacio; Freeze, B. Scott; Xia, Shujun; Horwitz, Susan Band. Design, Synthesis, and Biological Evaluation of Potent Discodermolide Fluorescent and Photoaffinity Molecular Probes. Organic Letters (2005), 7(23), 5199-5202.
464	Smith, Amos B., III; Adams, Christopher M. Evolution of Dithiane-Based Strategies for the Construction of Architecturally Complex Natural Products. Accounts of Chemical Research (2004), 37(6), 365-377.
462	Burlingame, Mark A.; Shaw, Simon J.; Sundermann, Kurt F.; Zhang, Dan; Petryka, Joseph; Mendoza, Esteban; Liu, Fenghua; Myles, David C.; LaMarche, Matthew J.; Hirose, Tomoyasu; Freeze, B. Scott; Smith, Amos B. Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues. Bioorganic & Medicinal Chemistry Letters (2004), 14(9), 2335-2338.
451	Smith, Amos B.; Freeze, B. Scott; Brouard, Ignacio; Hirose, Tomoyasu. A Practical Improvement, Enhancing the Large-Scale Synthesis of (+)-Discodermolide: A Third-Generation Approach. Organic Letters (2003), 5 (23), 4405-4408.
419	Martello, L. A.; LaMarche, M. J.; He, L.; Beauchamp, T. J.; Smith, A. B.; Horwitz, S. B. The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. Chemistry & Biology (2001), 8(9), 843-855.
412	Smith, Amos B., III; LaMarche, Matthew J.; Falcone-Hindley, Margaret. Solution Structure of (+)-Discodermolide. Organic Letters (2001), 3(5), 695-698.
400	Smith, Amos B., III; Beauchamp, Thomas J.; LaMarche, Matthew J.; Kaufman, Michael D.; Qiu, Yuping; Arimoto, Hirokazu; Jones, David R.; Kobayashi, Kaoru. Evolution of a Gram-Scale Synthesis of (+)-Discodermolide. Journal of the American Chemical Society (2000), 122(36), 8654-8664.
393	Martello, Laura A.; McDaid, Hayley M.; Regl, Donna Lee; Yang, Chia-Ping H.; Meng, Dongfang; Pettus, Thomas R. R.; Kaufman, Michael D.; Arimoto, Hirokazu; Danishefsky, Samuel J.; Smith, Amos B., III; Horwitz, Susan Band. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clinical Cancer Research (2000), 6(5), 1978-1987.
382	Smith, Amos B., III; Kaufman, Michael D.; Beauchamp, Thomas J.; LaMarche, Matthew J.; Arimoto, Hirokazu. Gram-Scale Synthesis of (+)-Discodermolide. Organic Letters (1999), 1(11), 1823-1826.
354	Smith, Amos B., III; Condon, Stephen M.; McCauley, John A. Total Synthesis of Immunosuppressants: Unified Strategies Exploiting Dithiane Couplings and s-Bond Olefin Constructions. Accounts of Chemical Research (1998), 31(1), 35-46.
313	Smith, Amos B., III; Qiu, Yuping; Jones, David R.; Kobayashi, Kaoru. Total Synthesis of (-)-Discodermolide. Journal of the American Chemical Society (1995), 117(48), 12011-12.