Publications -- View

The complete list of Professor Smith's publications are displayed in reverse chronological order. A search engine allows for searches by the first or last name of authors, keywords in the title and abstract. A convenient drop-down box makes it easy to search a specific journal or all journals with the desired keyword(s). The hits are all listed in reverse chronological order as well. When all boxes are filled out, the search will be the most specific since the boxes are connected with the "AND" logical operator.

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Total number of publications in this database: 541

Number
540	Parag P. Shah, Michael C. Myers, Mary Pat Beavers, Jeremy E. Purvis, Huiyan Jing, Heather J. Grieser, Elizabeth R. Sharlow, Andrew D. Napper, Donna M. Huryn, Barry S. Cooperman, Amos B. Smith III, and Scott L. Diamond. Kinetic Characterization and Molecular Docking of a Novel,Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L.Mol Pharmacol 2008 74: 34-41.
539	M. C. Myers, P. P. Shah, M. P. Beavers, A. D. Napper, S.L. Diamond, A. B. Smith, III and D. M. Huryn.Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. Bioorg. Med. Chem. Lett. 18 (2008) 3646–3651.
538	A. B. Smith, III, R. J. Fox, and T. M. Razler. Evolution of the Petasis-Ferrier Union/Rearrangement Tactic: Construction of Architecturally Complex Natural Products Possessing the Ubiquitous cis-2,6-Substituted Tetrahydropyran Structural Element. Acc. Chem. Res. 2008, 41, 675-687.
537	A. B. Smith, III, T. M. Razler, J. P. Ciavarri, T. Hirose, T. Ishikawa, and R. M. Meis. Synthesis and Biological Evaluation of Phorboxazole Congeners Leading to the Discovery and Preparative-Scale Synthesis of (+)-Chlorophorboxazole A Possessing Picomolar Human Solid Tumor Cell Growth Inhibitory Activity. J. Org. Chem. 2008, 73, 1201-1208.
536	A. B. Smith, III, T. M. Razler, J. P. Ciavarri, T. Hirose, T Ishikawa, and R. M. Meis. A Second-Generation Total Synthesis of (+)-Phorboxazole A. J. Org. Chem. 2008, 73, 1192-1200.
535	A. B. Smith, III, M. O. Duffey, K. Basu, S. P. Walsh, H. W. Suenneman, and M. Frohn. Total Syntheses of the Assigned Structures of Lituarines B and C. J. Am. Chem. Soc. 2008, 130, 422-423.
534	A. B. Smith, III and B. S. Freeze. (+)-Discodermalide: Total Syntheses, Construction of Novel Analogues, and Biological Evaluation: An Overview. Tetrahedron, 2008, 64, 261-298.
533	M. C. Myers, P. P. Shaha, S. L. Diamond, D. M. Hurynand A. B. Smith, III. Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg. Med. Chem. Lett. 2008, 18, 210-214.
532	A. B. Smith, III. Editorial 2008, Org. Lett. 2008, 10, 1-3.
531	A. B. Smith, III, K. Basu, and T Bosanac. Total Synthesis of (-)-Okilactomycin. J. Am. Chem. Soc. 2007, 129, 14872-14874.
530	H. Xie, D. Mg, S. Savinov, B. Dey, P.D. Kwong, R. Wyatt, A. B. Smith, III, and W. A. Kendrickson. Structure-Activity Relationships in the Binding of Chemically Derivatized CD4 to gp120 from Human Immunodeficiency Virus. J. Med. Chem. 2007, 50, 4898-4908.
529	S. Shaw, H. Menzella, D. C. Myles, M. Xian, and A. B. Smith, III. Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product-a further simplification of the lactone region. Organic & Biomolecular Chemistry. 2007, 5, 2753-2755.
528	A. B. Smith and D. Lee. Total Synthesis of (+)-Tedanolide. J. Am. Chem. Soc. 2007, 129, 10957-10962.
527	A. B. Smith, III, J. B. Sperry, and Q. Han. Syntheses of (-)-Oleocanthal, a Natural NSAID Found in Extra Virgin Olive Oil, the (-)-Deacetoxy-Oleuropein Aglycone, and Related Analogues. J. Org. Chem. 2007, 72, 6891-6900.
526	M. C. Myers, A. D. Napper, N. Moltekar, P. P. Shah, C. Chiu, M. P. Beavers, S. L. Diamond, D. M. Huryn, and A. B. Smith, III. Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: The confounding effects of DTT and cysteine in biological assays. Bioorg. Med. Chem. Lett. 2007, 17, 4761-4766.
525	A. B. Smith, III and D. S. Kim. The Spirastrellolides: Construction of the Southern C(1)-C(25) Fragment Exploiting Anion Relay Chemistry. Organic Letters. 2007, 17, 3311-3314.
524	A. B. Smith, III, D. S. Kim, and M. Xian. Anion Relay Chemistry Extended. Synthesis of a Gorgonian Sesquiterpene. Organic Letters. 2007, 17 3307-3309.
523	Paclitaxel C-10 carbamates: Potential candidates for the treatment of neurodegenerative tauopathies. C. Ballatore, E. Hyde, R. Deicher, V. Lee, J. Q. Trojanowski, D. Huryn, and A. B. Smith, III. Bioorg. Med. Chem. Lett. 2007, 17, 3642-3646.
522	A. B. Smith, III, L. Kurti, A. H. Davulcu, Y.-S. Cho, H. Ishiyama, and K. Ohmoto. Indole Diterpene Synthetic Studies: Development of a Second-Generation Synthetic Strategy for (+)-Nodulisporic Acids A and B. J. Org. Chem. 2007, 72, 4611-4620.
521	A. B. Smith, III, L. Kurti, A. H. Davulcu, Y.-S. Cho, H. Ishiyama, and K. Ohmoto. Indole Diterpene Synthetic Studies: Total Synthesis of (+)-Nodulisporic Acid F and Construction of the Heptacyclic Cores of (+)-Nodulisporic Acids A and B and (-)-Nodulisporic Acid D. J. Org. Chem. 2007, 72, 4596-4610.
520	S. Bagchi, Y.S. Kim, A.K. Charnley, A.B. Smith, III, and R.M. Hochstrasser. Two-Dimensional Infrared Investigation of N-Acetyl Tryptophan Methyl Amide in Solution. J. Phys. Chem. 2007, 111, 3010-3018.
519	D. C. Beshore and A. B. Smith, III. Total Syntesis of (+)-Lyconadin A and (-)-Lyconadin B. J. Am. Chem. Soc. 2007, 129, 4148-4149.
518	A. B. Smith, III, L. Kürti, and A. H. Davulcu. Development of a Scalable Synthesis of a Common Eastern Tricyclic Lactone for Construction of the Nodulisporic Acids. Org. Proc. Res. Dev. 2007, 11 (1) 19-24.
517	B. P. Mowery, V. Prasad, C. S. Kenesky, A. R. Angeles, L. L. Taylor, J.-J. Feng, W.-L. Chen, A. Lin, F.-C. Cheng, A. B. Smith, III, and R. Hirschmann. Catechol: A Minimal Scaffold for Non-Peptide Mimetics of the i+1 and i+2 Positions of β-turns. Application to Somatostatin. Org. Lett. 2006, 8, 4397-4400.
516	S. Xian, C. Kenesky, P. V Rucker, A. B. Smith, III, G. A. Orr, and S. B. Horwitz. A Photoaffinity Analogue of Discodermolide Specifically Labels a Peptide in -Tubulin. Biochemistry. 2006, 45, 11762-11775.
515	A. Schön, J. C. Klein, N. Madani, D. Ng, A. B. Smith, III, J. Sodroski, and E. Freire. Binding Thermodynamics of a Small Molecular Weight CD4 Mimetic to NIV-1 gp120. Biochemistry. 2006, 45, 10973-10980.
514	A. B. Smith, III, M. Xian, and W.-S. Kim. The [1,5]-Brook Rearrangement: An Initial Application in Anion Relay Chemistry. J. Am. Chem. Soc. 2006, 128, 12368-12369.
513	P. J. Stephens, D. M. McCann, F. J. Devlin, and A. B. Smith, III. Determination of the Absolute Configurations of Natural Products via Density Functional Theory Calculations of Optical Rotation, Electronic Circular Dichroism and Vibrational Circular Dichroism: the Cytotoxic Sesqquiterpene Natural Products Quadrone, Subersenone, Suberosanone and Suberosenol A Acetate. J. Nat. Prod. 2006, 69 1055-1064.
512	A. B. Smith, III and V. Simov. Total Synthesis of the Marine Natural Product (–)-Clavosolide A. A Showcase for the Petasis-Ferrier Union/Rearrangement Tactic. Org. Lett. 2006, 8, 3315-3318.
511	A. B. Smith, III, L. Kurti, and A. H. Davulcu. A New Modular Indole Synthesis. Construction of the Highly Strained CDEF Parent Tetracycle of Nodulisporic Acids A and B. Org. Lett. 2006, 8, 2167-2170.
510	A. B. Smith, III, A. H. Davulcu, and L. Kurti. Indole Diterpenoid Synthetic Studies. Construction of the Heptacyclic Core of (-)-Nodulisporic Acid D. Org. Lett. 2006, 8, 1699-1672.
509	A. B. Smith, III, A. H. Davulcu, and L. Kurti. Indole Diterpenoid Synthetic Studies. The Total Synthesis of (+)-Nodulisporic Acid F. Org. Lett. 2006, 8, 1665-1668.
508	A. B. Smith, III, and D.-S. Kim. A General, Convergent Strategy for the Construction of Indolizidine Alkaloids: Total Synthesis of (-)- Indolizidine 223AB and Alkaloid (-)-205B. J. Org. Chem. 2006, 71, 2547-2557.
507	A. B. Smith, III, E. F. Mesaros, and E. A. Meyer. Evolution of a Total Synthesis of (-)-Kendomycin Exploiting a Petasis-Ferrier Rearrangement/Ring-Closing Olefin Metathesis Strategy. J. Am. Chem Soc. 2006, 128, 5292-5299.
506	S. Foister, L. L. Taylor, J.-J. Feng, W.-L. Chen, A. Lin, F.-C. Cheng, A. B. Smith, III, and R. F. Hirschmann. Design and Synthesis of a Potent Cystine-Free Cyclic Hexapeptide Agonist at the Human Urotensin Receptor. Org. Lett. 2006, 7, 1799-1802.
505	A. B.Smith, III, T. M. Razler, R. M. Meis, and G. R. Pettit. The Design and Synthesis of a Potent Phorboxazole C(11-15) Acetal Analogue. Org. Lett. 2006, 7, 797-799.
504	G. S. Hung, L. Lopez-Barcons, R. Perez-Soler, B. S. Freeze, A. B. Snith, III, G. L. Goldberg, S. B. Horowitz, and H. McDaid. Potentiation of Taxol Efficacy by Discodermolide in Ovarian Carcinoma Xenograft-bearing Mice. Clin. Cancer Res. 2006, 12, 298-304.
503	A. B. Smith, III, and M. Xian. Anion Relay Chemistry: An Effective Tactic for Diversity Oriented Synthesis. J. Am. Chem. Soc. 2006, 128, 66-67.
502	A. B. smith, A. K. Charnley, H. Harada, J. J. Beiger, L.-D. Cantin, C.S. Kenesky, R. Hirschmann, S. Munshi, D. B. Olsen, M. W. Stahlhut, W. A. Schleif, and L. C. Kuo. Design, Synthesis and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors Possessing Augmented P2 Side-Chains. Bioorg. Med. Chem. Lett. 2006, 16, 859-863.
501	A. B. Smith, III, J. J. Beiger, A. H. Davulcu, and J. M. Cox. Preparation of [1-(methoxymethylcarbamoyl)ethyl]phosphonic acid bis(2,2,2-trifluoroethyl) ester: A useful intermediate in the synthesis of Z-unsaturated N-methoxy-N-methylamides. Org. Syn. 2005, 82, 147-156.
500	S. Mani, H. Huang, S. Sandarababu, W. Liu, G. Kalpana, A. B. Smith, III, and S. B. Horowitz. Activation of the Steriod and Xenobiotic Receptor (hPXR or SXR) by Non-Taxane Microtubule Stabilizing Agents. Clin. Cancer Res. 2005, 11, 6359-6369.
499	Smith, Amos B., III; Xian, Ming. Design, Synthesis, and Biological Evaluation of Simplified Analogues of (+)-Discodermolide. Additional Insights on the Importance of the Diene, the C(7) Hydroxyl, and the Lactone. Organic Letters (2005), 7(23), 5229-5232.
498	S.Sun, S.E. Aspland, C. Ballatore, R. Castillo, A.B. Smith, III, and A.J. Castelino. The Design and Synthesis and Evaluation of Two Universal Doxorubicin-Linkers. Preparation of Conjugates that Retain Topiisomerase II Activity. Bioorg. Med. Chem. Lett. 2005, 16, 104-107.
497	Smith, Amos B., III; Rucker, Paul V.; Brouard, Ignacio; Freeze, B. Scott; Xia, Shujun; Horwitz, Susan Band. Design, Synthesis, and Biological Evaluation of Potent Discodermolide Fluorescent and Photoaffinity Molecular Probes. Organic Letters (2005), 7(23), 5199-5202.
495	Smith, Amos B., III; Han, Qiang; Breslin, Paul A. S.; Beauchamp, Gary K. Synthesis and Assignment of Absolute Configuration of (-)-Oleocanthal: A Potent, Naturally Occurring Non-steroidal Anti-inflammatory and Anti-oxidant Agent Derived from Extra Virgin Olive Oils. Organic Letters (2005), 7(22), 5075-5078.
494	Smith, Amos B., III; Xian, Ming; Liu, Fenghua. Design, Total Synthesis, and Evaluation of C(13)-C(14) Cyclopropane Analogues of (+)-Discodermolide. Organic Letters (2005), 7(21), 4613-4616.
493	Fuertes, Michael J.; Kaur, Jaskiran; Deb, Prasant; Cooperman, Barry S.; Smith, Amos B.. Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase. Bioorganic & Medicinal Chemistry Letters (2005), 15(23), 5146-5149.
492	Smith, Amos B., III; Razler, Thomas M.; Ciavarri, Jeffrey P.; Hirose, Tomoyasu; Ishikawa, Tomoyasu. (+)-Phorboxazole A Synthetic Studies. A Highly Convergent, Second Generation Total Synthesis of (+)-Phorboxazole A. Organic Letters (2005), 7(20), 4399-4402.
491	Smith, Amos B., III; Razler, Thomas M.; Pettit, George R.; Chapuis, Jean-Charles. (+)-Phorboxazole A Synthetic Studies. Identification of a Series of Highly Cytotoxic C(45-46) Analogues. Organic Letters (2005), 7(20), 4403-4406.
490	Beauchamp, Gary K.; Keast, Russell S. J.; Morel, Diane; Lin, Jianming; Pika, Jana; Han, Qiang; Lee, Chi-Ho; Smith, Amos B.; Breslin, Paul A. S. Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil. Nature (London, United Kingdom) (2005), 437(7055), 45-46.
489	Cho, Cheon-Gyu; Kim, Won-Suk; Smith, Amos B., III. A Scalable Route to Trisubstituted (E)-Vinyl Bromides. Organic Letters (2005), 7(16), 3569-3572. CODEN: ORLEF7 ISSN:1523-7060.
488	Ballatore, Carlo; Aspland, Simon E.; Castillo, Rosario; Desharnais, Joel; Eustaquio, Trisha; Sun, Chengzao; Castellino, Angelo J.; Smith, Amos B.. A facile route to paclitaxel C-10 carbamates. Bioorganic & Medicinal Chemistry Letters (2005), 15(10), 2477-2480.
487	Smith, Amos B., III; Freeze, B. Scott; LaMarche, Matthew J.; Sager, Jason; Kinzler, Kenneth W.; Vogelstein, Bert. Discodermolide analogues as the chemical component of combination bacteriolytic therapy. Bioorganic & Medicinal Chemistry Letters (2005), 15(15), 3623-3626.
486	Neelamkavil, Santhosh; Arison, Byron; Birzin, Elizabeth; Feng, Jin-Jye; Chen, Kuo-Hsin; Lin, Atsui; Cheng, Fong-Chi; Taylor, Laurie; Thornton, Edward R.; Smith, Amos B., III; Hirschmann, Ralph. Replacement of Phe6, Phe7, and Phe11 of D-Trp8-Somatostatin-14 with L-Pyrazinylalanine. Predicted and Observed Effects on Binding Affinities at hSST2 and hSST4. An Unexpected Effect of the Chirality of Trp8 on NMR Spectra in Methanol. Journal of Medicinal Chemistry (2005), 48(12), 4025-4030.
485	Smith, Amos B., III; Kim, Dae-Shik. Total Synthesis of the Neotropical Poison-Frog Alkaloid (-)-205B. Organic Letters (2005), 7(15), 3247-3250.
484	Smith, Amos B., III; Fox, Richard J.; Vanecko, John A. (+)-Sorangicin A Synthetic Studies. Construction of the C(1-15) and C(16-29) Subtargets. Organic Letters (2005), 7(14), 3099-3102.
483	J.Q. Trojanovsky, A.B. Smith, III, D. Huryn, and M.-Y. Lee. Microtubule Stabilizing Drugs for Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders With Axonal Transport Impairments. Expert Opin. Pharmacother. 2005, 6, 683-685
482	Klein Laura E; Freeze B Scott; Smith Amos B 3rd; Horwitz Susan Band The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell cycle (Georgetown, Tex.) (2005), 4(3), 501-7.
481	Sunazuka, Toshiaki; Hirose, Tomoyasu; Chikaraishi, Noriko; Harigaya, Yoshihiro; Hayashi, Masahiko; Komiyama, Kanki; Sprengeler, Paul A.; Smith, Amos B.; Omura, Satoshi. Absolute stereochemistries and total synthesis of (+)/(-)-macrosphelides, potent, orally bioavailable inhibitors of cell-cell adhesion. Tetrahedron (2005), 61(15), 3789-3803.
480	Smith, Amos B., III; Mesaros, Eugen F.; Meyer, Emmanuel A. Total Synthesis of (-)-Kendomycin Exploiting a Petasis-Ferrier Rearrangement/Ring-Closing Olefin Metathesis Synthetic Strategy. Journal of the American Chemical Society (2005), 127(19), 6948-6949.
479	Shaw, Simon J.; Sundermann, Kurt F.; Burlingame, Mark A.; Myles, David C.; Freeze, B. Scott; Xian, Ming; Brouard, Ignacio; Smith, Amos B., III. Toward Understanding How the Lactone Moiety of Discodermolide Affects Activity. Journal of the American Chemical Society (2005), 127(18), 6532-6533.
478	Smith, Amos B., III; Freeze, B. Scott; Xian, Ming; Hirose, Tomoyasu. Total Synthesis of (+)-Discodermolide: A Highly Convergent Fourth-Generation Approach. Organic Letters (2005), 7(9), 1825-1828.
477	Angeles, Angie R.; Neagu, Irina; Birzin, Elizabeth T.; Thornton, Edward R.; Smith, Amos B., III; Hirschmann, Ralph. Synthesis and Binding Affinities of Novel SRIF-Mimicking b-D-Glucosides Satisfying the Requirement for a p-Cloud at C1. Organic Letters (2005), 7(6), 1121-1124.
476	Neelamkavil, S.; Mowery, B. P.; Thornton, E. R.; Smith, A. B., III; Hirschmann, R. A practical synthesis of Na-Fmoc-L-pyrazinylalanine via Schoellkopf's chiral auxiliary. Journal of Peptide Research (2005), 65(1), 139-142.
475	Smith, Amos B., III; Charnley, Adam K.; Mesaros, Eugen F.; Kikuchi, Osamu; Wang, Wenyong; Benowitz, Andrew; Chu, Chi-Lien; Feng, Jin-Jye; Chen, Kuo-Hsin; Lin, Atsui; Cheng, Fong-Chi; Taylor, Laurie; Hirschmann, Ralph. Design, Synthesis, and Binding Affinities of Pyrrolinone-Based Somatostatin Mimetics. Organic Letters (2005), 7(3), 399-402.
474	Smith, Amos B., III; Freeze, B. Scott; LaMarche, Matthew J.; Hirose, Tomoyasu; Brouard, Ignacio; Rucker, Paul V.; Xian, Ming; Sundermann, Kurt F.; Shaw, Simon J.; Burlingame, Mark A.; Horwitz, Susan Band; Myles, David C. Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide. Organic Letters (2005), 7(2), 311-314.
473	Smith, Amos B., III; Rucker, Paul V.; Brouard, Ignacio; Freeze, B. Scott; Xia, Shujun; Horwitz, Susan Band. Design, Synthesis, and Biological Evaluation of Potent Discodermolide Fluorescent and Photoaffinity Molecular Probes. Organic Letters (2005), 7(23), 5199-5202.
472	Smith, Amos B., III; Walsh, Shawn P.; Frohn, Michael; Duffey, Matthew O. Diversity-Oriented Synthesis of Polyketide Natural Products via Iterative Chemo- and Stereoselective Functionalization of Polyenoates: Development of a Unified Approach for the C(1-19) Segments of Lituarines A-C. Organic Letters (2005), 7(1), 139-142.
471	Smith, Amos B., III. Editorial 2005. Organic Letters (2005), 7(1), 1-2.
470	Smith, Amos B., III; Sfouggatakis, Chris; Gotchev, Dimitar B.; Shirakami, Shohei; Bauer, David; Zhu, Wenyu; Doughty, Victoria A. Spongistatin Synthetic Studies. Evolution of a Scalable Synthesis for the EF Fragment of (+)-Spongistatin 1 Exploiting a Petasis-Ferrier Union/Rearrangement Tactic. Organic Letters (2004), 6(20), 3637-3640.
469	ang, Jiangyong; Mei, Erwen; Green, Clive; Kaplan, Justin; DeGrado, William F.; Smith, Amos B., III; Hochstrasser, Robin M. Probing structural dynamics of individual calmodulin: peptide complexes in hydrogels by single-molecule confocal microscopy. Journal of Physical Chemistry B (2004), 108(40), 15910-15918.
468	Smith, Amos B., III; Adams, Christopher M.; Barbosa Lodise, Stephanie A.; Degnan, Andrew P.. A unified approach to the tedanolides: Total synthesis of (+)-13-deoxytedanolide. Proceedings of the National Academy of Sciences of the United States of America (2004), 101(33), 12042-12047.
467	Smith, Amos B., III; Duffey, Matthew O.. Bifunctional molecular linchpins: A three-component coupling protocol employing 2-bromoallyltrimethylsilane. Synlett (2004), (8), 1363-1366.
466	Fang, C.; Wang, J.; Kim, Y. S.; Charnley, A. K.; Barber-Armstrong, W.; Smith, A. B., III; Decatur, S. M.; Hochstrasser, R. M. Two-Dimensional Infrared Spectroscopy of Isotopomers of an Alanine Rich a-Helix. Journal of Physical Chemistry B (2004), 108(29), 10415-10427.
465	Dang, Long H.; Bettegowda, Chetan; Agrawal, Nishant; Cheong, Ian; Huso, David; Frost, Philip; Loganzo, Frank; Greenberger, Lee; Barkoczy, Jozsef; Pettit, George R.; Smith, Amos B., III; Gurulingappa, Hallur; Khan, Saeed; Kinzler, Kenneth W.; Zhou, Shibin; Vogelstein, Bert. Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents. Cancer Biology & Therapy (2004), 3(3), 326-337.
464	Smith, Amos B., III; Adams, Christopher M. Evolution of Dithiane-Based Strategies for the Construction of Architecturally Complex Natural Products. Accounts of Chemical Research (2004), 37(6), 365-377.
463	A.B. Smith, III, and S.M. Pitram. 2-tetra-Butyldimethylsilyl-1,3-dithiane. Electronic Encyclopedia of Reagents for Organic Synthesis, ed. L. Paquette, P. Fuchs, D. Crich, and P. Wipf.
462	Burlingame, Mark A.; Shaw, Simon J.; Sundermann, Kurt F.; Zhang, Dan; Petryka, Joseph; Mendoza, Esteban; Liu, Fenghua; Myles, David C.; LaMarche, Matthew J.; Hirose, Tomoyasu; Freeze, B. Scott; Smith, Amos B. Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues. Bioorganic & Medicinal Chemistry Letters (2004), 14(9), 2335-2338.
461	Madani, Navid; Perdigoto, Ana Luisa; Srinivasan, Kumar; Cox, Jason M.; Chruma, Jason J.; LaLonde, Judith; Head, Martha; Smith, Amos B., III; Sodroski, Joseph G. Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155.Journal of Virology (2004), 78(7), 3742-3752.
460	Si, Zhihai; Madani, Navid; Cox, Jason M.; Chruma, Jason J.; Klein, Jeffrey C.; Schoen, Arne; Phan, Ngoc; Wang, Liping; Biorn, Alyssa C.; Cocklin, Simon; Chaiken, Irwin; Freire, Ernesto; Smith, Amos B., III; Sodroski, Joseph G. Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins. Proceedings of the National Academy of Sciences of the United States of America (2004), 101(14), 5036-5041.
459	Smith, Amos B., III; Kim, Dae-Shik. Multicomponent Linchpin Coupling of Silyl Dithianes Employing an N-Ts Aziridine as the Second Electrophile: Synthesis of (-)-Indolizidine 223AB. Organic Letters (2004), 6(9), 1493-1495.
458	Smith, Amos B., III; Fox, Richard J. Construction of a C(30-38) Dioxabicyclo[3.2.1]octane Subtarget for (+)-Sorangicin A, Exploiting a Regio- and Stereocontrolled Acid-Catalyzed Epoxide Ring Opening. Organic Letters (2004), 6(9), 1477-1480.
457	Smith, Amos B.; Chruma, Jason J.; Han, Qiang; Barbosa, Joseph. Complestatin synthetic studies: the effect of the amino acid configuration on peptide backbone conformation in the common western BCD macrocycle. Bioorganic & Medicinal Chemistry Letters (2004), 14(7), 1697-1702.
456	Abrous, Leiela; Jokiel, Patrick A.; Friedrich, Sarah R.; Hynes, John, Jr.; Smith, Amos B., III; Hirschmann, Ralph. Novel Chimeric Scaffolds to Extend the Exploration of Receptor Space: Hybrid b-D-Glucose-Benzoheterodiazepine Structures for Broad Screening. Effect of Amide Alkylation on the Course of Cyclization Reactions. Journal of Organic Chemistry (2004), 69(2), 280-302.
455	Smith, Amos B., III. The next five years. Organic Letters (2004), 6(1), 1-2.
454	Fang, C.; Wang, J.; Charnley, A. K.; Barber-Armstrong, W.; Smith, A. B.; Decatur, S. M.; Hochstrasser, R. M. Two-dimensional infrared measurements of the coupling between amide modes of an a-helix. Chemical Physics Letters (2003), 382(5,6), 586-592.
453	Smith, Amos B., III; Hirschmann, Ralph. Search for Biologically Active Peptidomimetics of beta-turns and beta-starnds. Designed Scaffolds and Serendipitious Observations. Peotide Revolution: Genomics, Proteomics & Therapeutics. Eds. M. Chorev and T.K. Sawyer. American Peptide Society, 2003.
452	Smith, Amos B., III; Cui, Haifeng. Indole-diterpene synthetic studies: Total synthesis of (-)-21-isopentenylpaxilline. Helvetica Chimica Acta (2003), 86(12), 3908-3938.
451	Smith, Amos B.; Freeze, B. Scott; Brouard, Ignacio; Hirose, Tomoyasu. A Practical Improvement, Enhancing the Large-Scale Synthesis of (+)-Discodermolide: A Third-Generation Approach. Organic Letters (2003), 5 (23), 4405-4408.
450	Sulfur. Smith, Amos B., III. Chemical & Engineering News (2003), 81(36), 60.
449	Smith, Amos B.; Pitram, Suresh M.; Boldi, Armen M.; Gaunt, Matthew J.; Sfouggatakis, Chris; Moser, William H. Multicomponent Linchpin Couplings. Reaction of Dithiane Anions with Terminal Epoxides, Epichlorohydrin, and Vinyl Epoxides: Efficient, Rapid, and Stereocontrolled Assembly of Advanced Fragments for Complex Molecule Synthesis. Journal of the American Chemical Society (2003), 125 (47), 14435-14445.
448	Smith, Amos B.; Pitram, Suresh M.; Fuertes, Michael J. (+)-Rimocidin Synthetic Studies. Construction of an Advanced C(1-18) Polyol Fragment. Organic Letters (2003), 5 (15), 2751-2754.
447	Smith, Amos B.; Cho, Young Shin; Pettit, G. Robert; Hirschmann, Ralph. Design, synthesis, and evaluation of azepine-based cryptophycin mimetics. Tetrahedron (2003), 59 (35), 6991-7009.
446	Smith, Amos B.; Kanoh, Naoki; Ishiyama, Haruaki; Minakawa, Noriaki; Rainier, Jon D.; Hartz, Richard A.; Cho, Young Shin; Cui, Haifeng; Moser, William H. Tremorgenic Indole Alkaloids. The Total Synthesis of (-)-Penitrem D. Journal of the American Chemical Society (2003), 125 (27), 8228-8237.
445	Prasad, Vidya; Birzin, Elizabeth T.; McVaugh, Cheryl T.; van Rijn, Rachel D.; Rohrer, Susan P.; Chicchi, Gary; Underwood, Dennis J.; Thornton, Edward R.; Smith, Amos B., III; Hirschmann, Ralph. Effects of Heterocyclic Aromatic Substituents on Binding Affinities at Two Distinct Sites of Somatostatin Receptors. Correlation with the Electrostatic Potential of the Substituents. Journal of Medicinal Chemistry (2003), 46(10), 1858-1869
444	Smith, Amos B., III; Cantin, Louis-David; Pasternak, Alexander; Guise-Zawacki, Lisa; Yao, Wenquin; Charnley, Adam K.; Barbosa, Joseph; Sprengeler, Paul A.; Hirschmann, Ralph; Munshi, Sanjeev; Olsen, David B.; Schleif, William A.; Kuo, Lawrence C. Design, Synthesis, and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors. Journal of Medicinal Chemistry (2003), 46(10), 1831-1844.
443	Savinov, Sergey N.; Hirschmann, Ralph; Benkovic, Stephen J.; Smith, Amos B. Investigation of an antibody-ligase. evidence for strain-induced catalysis. Bioorganic & Medicinal Chemistry Letters (2003), 13(7), 1321-1324
442	Murphy, Paul V.; O'Brien, Julie L.; Gorey-Feret, Lorraine J.; Smith, Amos B. Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds. Tetrahedron (2003), 59(13), 2259-2271.
441	Smith, Amos B., III; Zhu, Wenyu; Shirakami, Shohei; Sfouggatakis, Chris; Doughty, Victoria A.; Bennett, Clay S.; Sakamoto, Yasuharu. Total Synthesis of (+)-Spongistatin 1. An Effective Second-Generation Construction of an Advanced EF Wittig Salt, Fragment Union, and Final Elaboration. Organic Letters (2003), 5(5), 761-764.
440	Smith, Amos B.; Cui, Haifeng. Total Synthesis of (-)-21-Isopentenylpaxilline. Organic Letters (2003), 5(4), 587-590.
439	Smith, Amos B.; Adams, Christopher M.; Barbosa, Stephanie A. Lodise; Degnan, Andrew P. Total Synthesis of (+)-13-Deoxytedanolide. Journal of the American Chemical Society (2003), 125(2), 350-351.
438	Smith, Amos B.. Editorial 2003: Year Four. Organic Letters (2003), 5(1), 1-2.
437	Smith, Amos B., III; Pitram, Suresh M.; Gaunt, Matthew J.; Kozmin, Sergey A. Dithiane Additions to Vinyl Epoxides: Steric Control over the SN2 and SN2' Manifolds Journal of the American Chemical Society (2002), 124(49), 14516-14517.
436	Smith, Amos B.; Lee, Dongjoo; Adams, Christopher M.; Kozlowski, Marisa C. SmI2-Promoted Oxidation of Aldehydes in the Presence of Electron-Rich Heteroatoms. Organic Letters (2002), 4(25), 4539-4541.
435	Smith, Amos B., III; Savinov, Sergey N.; Manjappara, Uma V.; Chaiken, Irwin M. Peptide-small molecule hybrids via orthogonal deprotection-chemoselective conjugation to cysteine-anchored scaffolds. A model study. Organic Letters (2002), 4(23), 4041-4044.
434	Smith, Amos B.; Safonov, Igor G.; Corbett, R. Michael. Total Syntheses of (+)-Zampanolide and (+)-Dactylolide Exploiting a Unified Strategy. Journal of the American Chemical Society (2002), 124(37), 11102-11113.
433	Smith, Amos B.; Zheng, Junying. Total synthesis of (-)-salicylihalamide A and related congeners. Tetrahedron (2002), 58(32), 6455-6471.
432	Smith, Amos B.; Corbett, R. Michael; Pettit, George R.; Chapuis, Jean-Charles; Schmidt, Jean M.; Hamel, Ernest; Jung, M. Katherine. Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue. Bioorganic & Medicinal Chemistry Letters (2002), 12(15), 2039-2042.
431	P.V. Murphy, J.L. O'Brien, L.J. Gorey-Feret, and A.B. Smith, III. Structure-Based Design and Synthesis of HIV-1 Protease Inhibitors Employing b-D-Mannopyranoside Scaffolds. Bioorg. Med.Chem. Lett. 2002, 12, 1763-1766
430	Smith, Amos B., III; Doughty, Victoria A.; Sfouggatakis, Chris; Bennett, Clay S.; Koyanagi, Jyunichi; Takeuchi, Makoto. Spongistatin Synthetic Studies. An Efficient, Second-Generation Construction of an Advanced ABCD Intermediate. Organic Letters (2002), 4(5), 783-786.
429	Smith, Amos B., III; Safonov, Igor G. Total Synthesis of (+)-Dactylolide. Organic Letters (2002), 4(4), 635-637.
428	Smith, Amos B., III. Editorial: the first three years. Organic Letters (2002), 4(1), 1.
427	Smith, Amos B., III; Cho, Young Shin; Zawacki, Lisa E.; Hirschmann, Ralph; Pettit, George R. First Generation Design, Synthesis, and Evaluation of Azepine-Based Cryptophycin Analogues. Organic Letters (2001), 3(25), 4063-4066.
426	Smith, Amos B., III; Frohn, Michael. Lituarine Synthetic Studies. An Efficient, Stereocontrolled Construction of the Common C(7-19) Tricyclic Spiroketal Fragment. Organic Letters (2001), 3(24), 3979-3982.
425	Smith, Amos B., III; Cho, Young Shin; Ishiyama, Haruaki. Nodulisporic Acid A Synthetic Studies. 2. Construction of an Eastern Hemisphere Subtarget. Organic Letters (2001), 3(24), 3971-3974.
424	Smith, Amos B., III; Ishiyama, Haruaki; Cho, Young Shin; Ohmoto, Kazuyuki. Nodulisporic Acid A Synthetic Studies. 1. Overall Strategy and Construction of a Western Hemisphere Subtarget. Organic Letters (2001), 3(24), 3967-3970.
423	Smith, Amos B., III; Safonov, Igor G.; Corbett, R. Michael. Total Synthesis of (+)-Zampanolide. Journal of the American Chemical Society (2001), 123(49), 12426-12427.
422	P.V. Murphy, J.L. O'Brien, and A.B. Smith, III. Stereospecific syntheses of b-D-allopyranosides by dihydroxylation of b-D-erythro-2,3-dideoxyhex-2-enopyranosides. Carbohydr. Res. 2001, 334, 327-335
421	Smith, Amos B., III; Minbiole, Kevin P.; Freeze, Scott. Facile assembly of 2,4-orthogonally-functionalized oxazoles: useful bidirectional linchpins. Synlett (2001), (11), 1739-1742.
420	Smith, Amos B., III; Minbiole, Kevin P.; Verhoest, Patrick R.; Schelhaas, Michael. Total synthesis of (+)-phorboxazole A exploiting the Petasis-Ferrier rearrangement. Journal of the American Chemical Society (2001), 123(44), 10942-10953.
419	Martello, L. A.; LaMarche, M. J.; He, L.; Beauchamp, T. J.; Smith, A. B.; Horwitz, S. B. The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. Chemistry & Biology (2001), 8(9), 843-855.
418	417. S. B. Horwitz, L. A. Martello, C.- P. H. Yang, A. B. Smith, III, and H. M. McDaid, "Discodermolide and Taxol: A Synergistic Drug Combination in Human Carcinoma Cell Lines" In Anticancer Agents: Frontiers in Cancer Chemotherapy, Ojima, I.; Vite, G. D.; Karh-Heinz Altmann, K.-H. (eds.); ACS Symp. Series 796, American Chemical Society, Washington, D. C., 2001; pp 81-96.
417	Smith, Amos B., III; Adams, Christopher M.; Kozmin, Sergey A.; Paone, Daniel V. Total Synthesis of (-)-Cylindrocyclophanes A and F Exploiting the Reversible Nature of the Olefin Cross Metathesis Reaction. Journal of the American Chemical Society (2001), 123(25), 5925-5937.
416	Smith, Amos B., III; Zheng, Junying. A first generation total synthesis of (+)-salicylihalamide A. Synlett (2001), (Spec. Issue), 1019-1023.
415	Smith, Amos B., III; Brandt, Benjamin M. Total Synthesis of (-)-Callystatin A. Organic Letters (2001), 3(11), 1685-1688.
414	Smith, Amos B., III; Verhoest, Patrick R.; Minbiole, Kevin P.; Schelhaas, Michael. Total Synthesis of (+)-Phorboxazole A. Journal of the American Chemical Society (2001), 123(20), 4834-4836.
413	Abrous, Leiela; Hynes, John, Jr.; Friedrich, Sarah R.; Smith, Amos B., III; Hirschmann, Ralph. Design and Synthesis of Novel Scaffolds for Drug Discovery: Hybrids of b-D-Glucose with 1,2,3,4-Tetrahydrobenzo[e][1,4]diazepin-5-one, the Corresponding 1-Oxazepine, and 2- and 4-Pyridyldiazepines. Organic Letters (2001), 3(7), 1089-1092.
412	Smith, Amos B., III; LaMarche, Matthew J.; Falcone-Hindley, Margaret. Solution Structure of (+)-Discodermolide. Organic Letters (2001), 3(5), 695-698.
411	Smith, Amos B., III; Adams, Christopher M.; Kozmin, Sergey A. On the Reversible Nature of the Olefin Cross Metathesis Reaction. Journal of the American Chemical Society (2001), 123(5), 990-991.
410	Smith, Amos B., III; Lin, Qiyan; Doughty, Victoria A.; Zhuang, Linghang; McBriar, Mark D.; Kerns, Jeffrey K.; Brook, Christopher S.; Murase, Noriaki; Nakayama, Kiyoshi. The spongistatins: architecturally complex natural products. Part two. Synthesis of the C(29-51) subunit, fragment assembly, and final elaboration to (+)-spongistatin 2. Angewandte Chemie, International Edition (2001), 40(1), 196-199.
409	Smith, Amos B., III; Doughty, Victoria A.; Lin, Qiyan; Zhuang, Linghang; McBriar, Mark D.; Boldi, Armen M.; Moser, William H.; Murase, Noriaki; Nakayama, Kiyoshi; Sobukawa, Masao. The spongistatins: architecturally complex natural products - Part one: a formal synthesis of (+)-spongistatin 1 by construction of an advanced ABCD fragment. Angewandte Chemie, International Edition (2001), 40(1), 191-195.
408	Hirschmann, Ralph; Ducry, Laurent; Smith, Amos B., III. Development of an Efficient, Regio- and Stereoselective Route to Libraries Based on the b-D-Glucose Scaffold. Journal of Organic Chemistry (2000), 65(24), 8307-8316.
407	Smith, Amos B., III; Ducry, Laurent; Corbett, R. Michael; Hirschmann, Ralph. Intramolecular Hydrogen-Bond Participation in Phosphonylammonium Salt Formation. Organic Letters (2000), 2(24), 3887-3890.
406	Rainier, J. D.; Smith, A. B.. Polyene cyclizations to indole diterpenes. The first synthesis of (+)-emindole SA using a biomimetic approach. Tetrahedron Letters (2000), 41(49), 9419-9423.
405	Smith, Amos B., III; Nittoli, Thomas; Sprengeler, Paul A.; Duan, James J.-W.; Liu, Rui-Qin; Hirschmann, Ralph F. Design, Synthesis, and Evaluation of a Pyrrolinone-Based Matrix Metalloprotease Inhibitor. Organic Letters (2000), 2(24), 3809-3812.
404	Liu, Josephine; Underwood, Dennis J.; Cascieri, Margaret A.; Rohrer, Susan P.; Cantin, Louis-David; Chicchi, Gary; Smith, Amos B., III; Hirschmann, Ralph. Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry. Journal of Medicinal Chemistry (2000), 43(21), 3827-3831.
403	Smith, Amos B., III; Kanoh, Naoki; Ishiyama, Haruaki; Hartz, Richard A. Total Synthesis of (-)-Penitrem D. Journal of the American Chemical Society (2000), 122(45), 11254-11255.
402	Smith, Amos B., III; Wang, Wenyong; Sprengeler, Paul A.; Hirschmann, Ralph. Design, Synthesis, and Solution Structure of a Pyrrolinone-Based b-Turn Peptidomimetic. Journal of the American Chemical Society (2000), 122(44), 11037-11038.
401	Stetzer, M. R.; Heiney, P. A.; Stephens, P. W.; Dinnebier, R. E.; Zhu, Q.; McGhie, A. R.; Strongin, R. M.; Brandt, B. M.; Smith, A. B., III. Structure and phase transitions of the 6,6-cyclopropane isomer of C61H2. Physical Review B: Condensed Matter and Materials Physics (2000), 62(14), 9305-9316.
400	Smith, Amos B., III; Beauchamp, Thomas J.; LaMarche, Matthew J.; Kaufman, Michael D.; Qiu, Yuping; Arimoto, Hirokazu; Jones, David R.; Kobayashi, Kaoru. Evolution of a Gram-Scale Synthesis of (+)-Discodermolide. Journal of the American Chemical Society (2000), 122(36), 8654-8664.
399	Lee, Kon Ho; Olson, Gary L.; Bolin, David R.; Benowitz, Andrew B.; Sprengeler, Paul A.; Smith, Amos B., III; Hirschmann, Ralph F.; Wiley, Don C. The Crystal Structure of a Pyrrolinone-Peptide Hybrid Ligand Bound to the Human Class II MHC Protein HLA-DR1. Journal of the American Chemical Society (2000), 122(35), 8370-8375.
398	Smith, A. B., III; Org. Lett.; (Editorial); 2000; 2(1); 1-2.
397	Smith, Amos B. ,III; Liu, Hu; Okumura, Hiroyuki; Favor, David A.; Hirschmann, Ralph. Synthesis of Polypyrrolinones on Solid Support. Organic Letters (2000), 2(14), 2041-2044.
396	Smith, Amos B., III; Liu, Hu; Hirschmann, Ralph. A Second-Generation Synthesis of Polypyrrolinone Nonpeptidomimetics: Prelude to the Synthesis of Polypyrrolinones on Solid Support. Organic Letters (2000), 2(14), 2037-2040.
395	Kondru, Rama K.; Beratan, David N.; Friestad, Gregory K.; Smith, Amos B., III; Wipf, Peter. Chiral Action at a Distance: Remote Substituent Effects on the Optical Activity of Calyculins A and B. Organic Letters (2000), 2(11), 1509-1512.
394	Smith, Amos B., III; Wan, Zehong. Total Synthesis of the Ansamycin Antibiotic (+)-Thiazinotrienomycin E. Journal of Organic Chemistry (2000), 65(12), 3738-3753.
393	Martello, Laura A.; McDaid, Hayley M.; Regl, Donna Lee; Yang, Chia-Ping H.; Meng, Dongfang; Pettus, Thomas R. R.; Kaufman, Michael D.; Arimoto, Hirokazu; Danishefsky, Samuel J.; Smith, Amos B., III; Horwitz, Susan Band. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clinical Cancer Research (2000), 6(5), 1978-1987.
392	Smith, Amos B. III; Kozmin, Sergey A.; Adams, Christopher M.; Paone, Daniel V. Assembly of (-)-Cylindrocyclophanes A and F via Remarkable Olefin Metathesis Dimerizations. Journal of the American Chemical Society (2000), 122(20), 4984-4985.
391	Smith, Amos B., III; Sestelo, Jose Perez; Dormer, Peter G. A highly efficient synthetic route to (-)-furaquinocin C. Heterocycles (2000), 52(3), 1315-1328.
390	Sunazuka, Toshiaki; Hirose, Tomoyasu; Shirahata, Tatsuya; Harigaya, Yoshihiro; Hayashi, Masahiko; Komiyama, Kanki; Omura, Satoshi; Smith, Amos B., III. Total Synthesis of (+)-Madindoline A and (-)-Madindoline B, Potent, Selective Inhibitors of Interleukin 6. Determination of the Relative and Absolute Configurations. Journal of the American Chemical Society (2000), 122(9), 2122-2123.
389	Smithrud, David B.; Benkovic, Patricia A.; Benkovic, Stephen J.; Roberts, Victoria; Liu, Josephine; Neagu, Irina; Iwama, Seiji; Phillips, Barton W.; Smith, Amos B.; Hirschmann, Ralph. Cyclic peptide formation catalyzed by an antibody ligase. Proceedings of the National Academy of Sciences of the United States of America (2000), 97(5), 1953-1958.
388	Schiller, Peter W.; Berezowska, Irena; Nguyen, Thi M.-D.; Schmidt, Ralf; Lemieux, Carole; Chung, Nga N.; Falcone-Hindley, Margaret L.; Yao, Wenqing; Liu, Josephine; Iwama, Seiji; Smith, Amos B., III; Hirschmann, Ralph. Novel Ligands Lacking a Positive Charge for the d- and m-Opioid Receptors. Journal of Medicinal Chemistry (2000), 43(4), 551-559.
387	Amith, Amos B., III. Organic Letters - Editorial 2000. Organic Letters (2000), 2(1), 1-2.
386	Smith, Amos B., III; Pitram, Suresh M. Multicomponent Linchpin Couplings of Silyl Dithianes: Synthesis of the Schreiber C(16-28) Trisacetonide Subtarget for Mycoticins A and B. Organic Letters (1999), 1(12), 2001-2004.
385	Smith, Amos B., III; Empfield, James R. Synthetic strategies towards the total synthesis of phyllanthocin and breynolide. Application of stereochemically linear and convergent strategies. Chemical & Pharmaceutical Bulletin (1999), 47(12), 1671-1678.
384	Smith, Amos B., III; Friestad, Gregory K.; Barbosa, Joseph; Bertounesque, Emmanuel; Duan, James J.-W.; Hull, Kenneth G.; Iwashima, Makoto; Qiu, Yuping; Spoors, P. Grant; Salvatore, Brian A. Total Synthesis of (+)-Calyculin A and (-)-Calyculin B: Cyanotetraene Construction, Asymmetric Synthesis of the C(26-37) Oxazole, Fragment Assembly, and Final Elaboration. Journal of the American Chemical Society (1999), 121(45), 10478-10486.
383	Smith, Amos B., III; Friestad, Gregory K.; Barbosa, Joseph; Bertounesque, Emmanuel; Hull, Kenneth G.; Iwashima, Makoto; Qiu, Yuping; Salvatore, Brian A.; Spoors, P. Grant; Duan, James J.-W. Total Synthesis of (+)-Calyculin A and (-)-Calyculin B: Asymmetric Synthesis of the C(9-25) Spiroketal Dipropionate Subunit. Journal of the American Chemical Society (1999), 121(45), 10468-10477.
382	Smith, Amos B., III; Kaufman, Michael D.; Beauchamp, Thomas J.; LaMarche, Matthew J.; Arimoto, Hirokazu. Gram-Scale Synthesis of (+)-Discodermolide. Organic Letters (1999), 1(11), 1823-1826.
381	Smith, Amos B., III; Wan, Zehong. Total Synthesis of (+)-Thiazinotrienomycin E. Organic Letters (1999), 1(9), 1491-1494.
380	Smith, Amos B., III; Kanoh, Naoki; Minakawa, Noriaki; Rainier, Jon D.; Blase, Frances R.; Hartz, Richard A. Tremorgenic Indole Alkaloids. Studies Directed toward the Assembly of the A, F, and I Rings of Penitrem D: Observation of an Unexpected Stereochemical Outcome. Organic Letters (1999), 1(8), 1263-1266.
379	Smith, Amos B., III; Benowitz, Andrew B.; Sprengeler, Paul A.; Barbosa, Joseph; Guzman, Mark C.; Hirschmann, Ralph; Schweiger, Edwin J.; Bolin, David R.; Nagy, Zoltan; Campbell, Robert M.; Cox, Donald C.; Olson, Gary L. Design and Synthesis of a Competent Pyrrolinone-Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1. Journal of the American Chemical Society (1999), 121(40), 9286-9298.
378	Smith, Amos B., III; Lodise, Stephanie A. Synthesis of Tedanolide and 13-Deoxytedanolide. Assembly of a Common C(1)-C(11) Subtarget. Organic Letters (1999), 1(8), 1249-1252.
377	Liehr, Sebastian; Barbosa, Joseph; Smith, Amos B., III; Cooperman, Barry S. Synthesis and biological activity of cyclic peptide inhibitors of ribonucleotide reductase. Organic Letters (1999), 1(8), 1201-1204.
376	Smith, Amos B., III; Minbiole, Kevin P.; Verhoest, Patrick R.; Beauchamp, Thomas J. Phorboxazole Synthetic Studies. 2. Construction of a C(20-28) Subtarget, a Further Extension of the Petasis-Ferrier Rearrangement. Organic Letters (1999), 1(6), 913-916.
375	Smith, Amos B., III; Verhoest, Patrick R.; Minbiole, Kevin P.; Lim, John J. Phorboxazole Synthetic Studies. 1. Construction of a C(3-19) Subtarget Exploiting an Extension of the Petasis-Ferrier Rearrangement. Organic Letters (1999), 1(6), 909-912.
374	Heiney, Paul A.; Stetzer, MacKenzie R.; Mindyuk, Oksana Y.; DiMasi, Elaine; McGhie, Andrew R.; Liu, Hu; Smith, Amos B. III. Langmuir Films of Amphiphilic Crown Ethers. Journal of Physical Chemistry B (1999), 103(30), 6206-6214.
373	Smith, III, A. B.; “Editorial”; Org. Lett. 1, 1 (1999).
372	Soli, Eric D.; Manoso, Amy S.; Patterson, Michael C.; DeShong, Philip; Favor, David A.; Hirschmann, Ralph; Smith, Amos B., III. Azide and Cyanide Displacements via Hypervalent Silicate Intermediates. [Erratum to document cited in CA130:296920]. Journal of Organic Chemistry (1999), 64(17), 6526.
371	Smith, Amos B., III; Kozmin, Sergey A.; Paone, Daniel V. Total Synthesis of (-)-Cylindrocyclophane F. Journal of the American Chemical Society (1999), 121(32), 7423-7424.
370	Smith, Amos B., III; Kanoh, Naoki; Minakawa, Noriaki; Rainier, Jon D.; Hartz, Richard A.; Clark, William M.; Haseltine, John N. Total synthesis of penitrem D. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (1999), 41st 55-60.
369	Sunazuka, T.; Hirose, T.; Shirahata, T.; Harigaya, Y.; Hayashi, M.; Komiyama, K.; Smith, A. B., III; Omura, S. Relative and absolute stereochemistries and total syntheses of madindolines A and B, potent, selective inhibitors of IL-6 activity. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (1999), 41st 49-54.
368	Smith, Amos B., III; Favor, David A.; Sprengeler, Paul A.; Guzman, Mark C.; Carroll, Patrick J.; Furst, George T.; Hirschmann, Ralph. Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold. Bioorganic & Medicinal Chemistry (1999), 7(1), 9-22.
367	Smith, Amos B., III; Sasho, Setsuya; Barwis, Bari A.; Sprengeler, Paul; Barbosa, Joseph; Hirschmann, Ralph; Cooperman, Barry S. Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase. Bioorganic & Medicinal Chemistry Letters (1998), 8(22), 3133-3136.
366	Smith, Amos B., III; Cho, Young Shin; Friestad, Gregory K. Convenient Wacker oxidations with substoichiometric cupric acetate. Tetrahedron Letters (1998), 39(48), 8765-8768.
365	Smith, Amos B. ,III; Benowitz, Andrew B.; Guzman, Mark C.; Sprengeler, Paul A.; Hirschmann, Ralph; Schweiger, Edwin J.; Bolin, David R.; Nagy, Zoltan; Campbell, Robert M.; Cox, Donald C.; Olson, Gary L. Design, synthesis, and evaluation of a pyrrolinone-peptide hybrid ligand for the class II MHC protein HLA-DR1. Journal of the American Chemical Society (1998), 120(48), 12704-12705.
364	Gidalevitz, David; Mindyuk, Oksana Y.; Stetzer, MacKenzie R.; Heiney, Paul A.; Kurnaz, M. Levent; Schwartz, Daniel K.; Ocko, Benjamin M.; McCauley, John P., Jr.; Smith, Amos B., III. A Conformational Phase Transition in a Langmuir Film of an Amphiphilic Azacrown. Journal of Physical Chemistry B (1998), 102(35), 6688-6691.
363	Smith, Amos B., III; Friestad, Gregory K.; Duan, James J.-W.; Barbosa, Joseph; Hull, Kenneth G.; Iwashima, Makoto; Qiu, Yuping; Spoors, P. Grant; Bertounesque, Emmanuel; Salvatore, Brian A. Total Synthesis of (+)-Calyculin A and (-)-Calyculin B. Journal of Organic Chemistry (1998), 63(22), 7596-7597.
362	Arimoto, Hirokazu; Kaufman, Michael D.; Kobayashi, Kaoru; Qiu, Yuping; Smith, Amos B., III. Anomalous epoxide formation upon Wittig olefination with 1-iodoethyl triphenylphosphonium ylide. Synlett (1998), (7), 765-767.
361	Khong, Anthony; Jimenez-Vazquez, Hugo A.; Saunders, Martin; Cross, R. James; Laskin, Julia; Peres, Tikva; Lifshitz, Chava; Strongin, Rob; Smith, Amos B., III. An NMR Study of He2 Inside C70. Journal of the American Chemical Society (1998), 120(25), 6380-6383.
360	Hirschmann, Ralph; Yao, Wenqing; Arison, Byron; Maechler, Laurie; Rosegay, Avery; Sprengeler, Paul A.; Smith, Amos B., III. Synthesis of the first tricyclic homodetic peptide. use of coordinated orthogonal deprotection to achieve directed ring closure. Tetrahedron (1998), 54(25), 7179-7202.
359	Smith, Amos B., III; Ott, Gregory R. Total Syntheses of (-)-Macrolactin A, (+)-Macrolactin E, and (-)-Macrolactinic Acid: An Exercise in Stille Cross-Coupling Chemistry. Journal of the American Chemical Society (1998), 120(16), 3935-3948.
358	Hirschmann, Ralph; Hynes, John, Jr.; Cichy-Knight, Maria A.; van Rijn, Rachel D.; Sprengeler, Paul A.; Spoors, P. Grant; Shakespeare, William C.; Pietranico-Cole, Sherrie; Barbosa, Joseph; Liu, Josephine; Yao, Wenqing; Rohrer, Susan; Smith, Amos B., III. Modulation of Receptor and Receptor Subtype Affinities Using Diastereomeric and Enantiomeric Monosaccharide Scaffolds as a Means to Structural and Biological Diversity. A New Route to Ether Synthesis. Journal of Medicinal Chemistry (1998), 41(9), 1382-1391.
357	Smith, Amos B., III; Barbosa, Joseph. (+)-Thiazinotrienomycin E: relative and absolute stereochemistry. Tetrahedron Letters (1998), 39(19), 2891-2894.
356	Sudoh, Masao; Pauletti, Giovanni M.; Yao, Wenqing; Moser, William; Yokoyama, Akihisa; Pasternak, Alexander; Sprengeler, Paul A.; Smith, Amos B., III; Hirschmann, Ralph; Borchardt, Ronald T. Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers. Pharmaceutical Research (1998), 15(5), 719-725.
355	Smith, Amos B.; Lin, Qiyan. Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains. Bioorganic & Medicinal Chemistry Letters (1998), 8(6), 567-568.
354	Smith, Amos B., III; Condon, Stephen M.; McCauley, John A. Total Synthesis of Immunosuppressants: Unified Strategies Exploiting Dithiane Couplings and s-Bond Olefin Constructions. Accounts of Chemical Research (1998), 31(1), 35-46.
353	A.B. Smith, III. Organic Syntheses, John Wiley & Son, Inc.: New York, 1997; Vol. 50.
352	Smith, Amos B., III; Chen, Sean S.-Y.; Nelson, Frances C.; Reichert, Janice M.; Salvatore, Brian A. Total Syntheses of (+)-Acutiphycin and (+)-trans-20,21-Didehydroacutiphycin. Journal of the American Chemical Society (1997), 119(45), 10935-10946.
351	Gidalevitz, David; Mindyuk, Oksana Y.; Heiney, Paul A.; Ocko, Benjamin M.; Henderson, Philippe; Ringsdorf, Helmut; Boden, Neville; Bushby, Richard J.; Martin, Philip S.; Strzalka, Joseph; McCauley, John P., Jr.; Smith, Amos B., III. Structure of Discotic Liquid Crystalline Compounds at the Air-Water Interface. Journal of Physical Chemistry B (1997), 101(50), 10870-10875.
350	Smith, Amos B., III; Lin, Qiyan; Nakayama, Kiyoshi; Boldi, Armen M.; Brook, Christopher S.; Mcbriar, Mark D.; Moser, William H.; Sobukawa, Masao; Zhuang, Linghang. Spongistatin synthetic studies. 3. Construction of the C(1-17) spiroketal. Tetrahedron Letters (1997), 38(50), 8675-8678.
349	Smith, Amos B., III; Zhuang, Linghang; Brook, Christopher S.; Lin, Qiyan; Moser, William H.; Trout, Robert E. Lee; Boldi, Armen M. Spongistatin synthetic studies. 2. Assembly of the C(18-28) spiroketal. Tetrahedron Letters (1997), 38(50), 8671-8674.
348	Smith, Amos B., III; Zhuang, Linghang; Brook, Christopher S.; Boldi, Armen M.; Mcbriar, Mark D.; Moser, William H.; Murase, Noriaki; Nakayama, Kiyoshi; Verhoest, Patrick R.; Lin, Qiyan. Spongistatin synthetic studies. 1. Construction of a C(29-48) subtarget. Tetrahedron Letters (1997), 38(50), 8667-8670.
347	Sunazuka, Toshiaki; Hirose, Tomoyasu; Harigaya, Yoshihiro; Takamatsu, Satoshi; Hayashi, Masahiko; Komiyama, Kanki; Omura, Satoshi; Sprengeler, Paul A.; Smith, Amos B., III. Relative and Absolute Stereochemistries and Total Synthesis of (+)-Macrosphelides A and B, Potent, Orally Bioavailable Inhibitors of Cell-Cell Adhesion. Journal of the American Chemical Society (1997), 119(42), 10247-10248.
346	K.Chen, C.S. Brook, and A.B. Smith, III. 6-7-Dihydrocyclopenta-1,3-dioxin-5(4H)-one. Org. Syn. 1997, 75, 189-194
345	A.B. Smith, III, K.M. Yager, B.W. Phillips, and C.M. Taylor. Enantiospecific Synthesis of Diethyl (R)-(-)-(1-Amino-3-methylbutyl) Phosphonate. Org. Syn. 1997, 75, 19-30
344	Hirschmann, Ralph; Yager, Kraig M.; Taylor, Carol M.; Witherington, Jason; Sprengeler, Paul A.; Phillips, Barton W.; Moore, William; Smith, Amos B., III. Phosphonate Diester and Phosphonamide Synthesis. Reaction Coordinate Analysis by 31P NMR Spectroscopy: Identification of Pyrophosphonate Anhydrides and Highly Reactive Phosphonylammonium Salts. Journal of the American Chemical Society (1997), 119(35), 8177-8190.
343	Obata, Rika; Sunazuka, Toshiaki; Tian, Zhiming; Tomoda, Hiroshi; Harigaya, Yoshihiro; Omura, Satoshi; Smith, Amos B., III. New analogs of the pyripyropene family of ACAT inhibitors via a-pyrone fragmentation and g-acylation/cyclization. Chemistry Letters (1997), (9), 935-936.
342	Smith, Amos B., III; Hartz, Richard A.; Spoors, P. Grant; Rainier, Jon D. Tremorgenic indole alkaloids. 10. An improved asymmetric synthesis of a tricyclic common intermediate. Israel Journal of Chemistry (1997), 37(1), 69-80.
341	Smith, Amos B., III; Hirschmann, Ralph; Pasternak, Alexander; Yao, Wenquing; Sprengeler, Paul A.; Holloway, M. Katharine; Kuo, Lawrence C.; Chen, Zhongguo; Darke, Paul L.; Schleif, William A. An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex. Journal of Medicinal Chemistry (1997), 40(16), 2440-2444.
340

Number

540

Parag P. Shah, Michael C. Myers, Mary Pat Beavers, Jeremy E. Purvis, Huiyan Jing, Heather J. Grieser, Elizabeth R. Sharlow, Andrew D. Napper, Donna M. Huryn, Barry S. Cooperman, Amos B. Smith III, and Scott L. Diamond. Kinetic Characterization and Molecular Docking of a Novel,Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L.Mol Pharmacol 2008 74: 34-41.

539

M. C. Myers, P. P. Shah, M. P. Beavers, A. D. Napper, S.L. Diamond, A. B. Smith, III and D. M. Huryn.Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. Bioorg. Med. Chem. Lett. 18 (2008) 3646–3651.

538

A. B. Smith, III, R. J. Fox, and T. M. Razler. Evolution of the Petasis-Ferrier Union/Rearrangement Tactic: Construction of Architecturally Complex Natural Products Possessing the Ubiquitous cis-2,6-Substituted Tetrahydropyran Structural Element. Acc. Chem. Res. 2008, 41, 675-687.

537

A. B. Smith, III, T. M. Razler, J. P. Ciavarri, T. Hirose, T. Ishikawa, and R. M. Meis. Synthesis and Biological Evaluation of Phorboxazole Congeners Leading to the Discovery and Preparative-Scale Synthesis of (+)-Chlorophorboxazole A Possessing Picomolar Human Solid Tumor Cell Growth Inhibitory Activity. J. Org. Chem. 2008, 73, 1201-1208.

536

A. B. Smith, III, T. M. Razler, J. P. Ciavarri, T. Hirose, T Ishikawa, and R. M. Meis. A Second-Generation Total Synthesis of (+)-Phorboxazole A. J. Org. Chem. 2008, 73, 1192-1200.

535

A. B. Smith, III, M. O. Duffey, K. Basu, S. P. Walsh, H. W. Suenneman, and M. Frohn. Total Syntheses of the Assigned Structures of Lituarines B and C. J. Am. Chem. Soc. 2008, 130, 422-423.

534

A. B. Smith, III and B. S. Freeze. (+)-Discodermalide: Total Syntheses, Construction of Novel Analogues, and Biological Evaluation: An Overview. Tetrahedron, 2008, 64, 261-298.

533

M. C. Myers, P. P. Shaha, S. L. Diamond, D. M. Hurynand A. B. Smith, III. Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg. Med. Chem. Lett. 2008, 18, 210-214.

532

A. B. Smith, III. Editorial 2008, Org. Lett. 2008, 10, 1-3.

531

A. B. Smith, III, K. Basu, and T Bosanac. Total Synthesis of (-)-Okilactomycin. J. Am. Chem. Soc. 2007, 129, 14872-14874.

530

H. Xie, D. Mg, S. Savinov, B. Dey, P.D. Kwong, R. Wyatt, A. B. Smith, III, and W. A. Kendrickson. Structure-Activity Relationships in the Binding of Chemically Derivatized CD4 to gp120 from Human Immunodeficiency Virus. J. Med. Chem. 2007, 50, 4898-4908.

529

S. Shaw, H. Menzella, D. C. Myles, M. Xian, and A. B. Smith, III. Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product-a further simplification of the lactone region. Organic & Biomolecular Chemistry. 2007, 5, 2753-2755.

528

A. B. Smith and D. Lee. Total Synthesis of (+)-Tedanolide. J. Am. Chem. Soc. 2007, 129, 10957-10962.

527

A. B. Smith, III, J. B. Sperry, and Q. Han. Syntheses of (-)-Oleocanthal, a Natural NSAID Found in Extra Virgin Olive Oil, the (-)-Deacetoxy-Oleuropein Aglycone, and Related Analogues. J. Org. Chem. 2007, 72, 6891-6900.

526

M. C. Myers, A. D. Napper, N. Moltekar, P. P. Shah, C. Chiu, M. P. Beavers, S. L. Diamond, D. M. Huryn, and A. B. Smith, III. Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: The confounding effects of DTT and cysteine in biological assays. Bioorg. Med. Chem. Lett. 2007, 17, 4761-4766.

525

A. B. Smith, III and D. S. Kim. The Spirastrellolides: Construction of the Southern C(1)-C(25) Fragment Exploiting Anion Relay Chemistry. Organic Letters. 2007, 17, 3311-3314.

524

A. B. Smith, III, D. S. Kim, and M. Xian. Anion Relay Chemistry Extended. Synthesis of a Gorgonian Sesquiterpene. Organic Letters. 2007, 17 3307-3309.

523

Paclitaxel C-10 carbamates: Potential candidates for the treatment of neurodegenerative tauopathies. C. Ballatore, E. Hyde, R. Deicher, V. Lee, J. Q. Trojanowski, D. Huryn, and A. B. Smith, III. Bioorg. Med. Chem. Lett. 2007, 17, 3642-3646.

522

A. B. Smith, III, L. Kurti, A. H. Davulcu, Y.-S. Cho, H. Ishiyama, and K. Ohmoto. Indole Diterpene Synthetic Studies: Development of a Second-Generation Synthetic Strategy for (+)-Nodulisporic Acids A and B. J. Org. Chem. 2007, 72, 4611-4620.

521

A. B. Smith, III, L. Kurti, A. H. Davulcu, Y.-S. Cho, H. Ishiyama, and K. Ohmoto. Indole Diterpene Synthetic Studies: Total Synthesis of (+)-Nodulisporic Acid F and Construction of the Heptacyclic Cores of (+)-Nodulisporic Acids A and B and (-)-Nodulisporic Acid D. J. Org. Chem. 2007, 72, 4596-4610.

520

S. Bagchi, Y.S. Kim, A.K. Charnley, A.B. Smith, III, and R.M. Hochstrasser. Two-Dimensional Infrared Investigation of N-Acetyl Tryptophan Methyl Amide in Solution. J. Phys. Chem. 2007, 111, 3010-3018.

519

D. C. Beshore and A. B. Smith, III. Total Syntesis of (+)-Lyconadin A and (-)-Lyconadin B. J. Am. Chem. Soc. 2007, 129, 4148-4149.

518

A. B. Smith, III, L. Kürti, and A. H. Davulcu. Development of a Scalable Synthesis of a Common Eastern Tricyclic Lactone for Construction of the Nodulisporic Acids. Org. Proc. Res. Dev. 2007, 11 (1) 19-24.

517

B. P. Mowery, V. Prasad, C. S. Kenesky, A. R. Angeles, L. L. Taylor, J.-J. Feng, W.-L. Chen, A. Lin, F.-C. Cheng, A. B. Smith, III, and R. Hirschmann. Catechol: A Minimal Scaffold for Non-Peptide Mimetics of the i+1 and i+2 Positions of β-turns. Application to Somatostatin. Org. Lett. 2006, 8, 4397-4400.

516

S. Xian, C. Kenesky, P. V Rucker, A. B. Smith, III, G. A. Orr, and S. B. Horwitz. A Photoaffinity Analogue of Discodermolide Specifically Labels a Peptide in -Tubulin. Biochemistry. 2006, 45, 11762-11775.

515

A. Schön, J. C. Klein, N. Madani, D. Ng, A. B. Smith, III, J. Sodroski, and E. Freire. Binding Thermodynamics of a Small Molecular Weight CD4 Mimetic to NIV-1 gp120. Biochemistry. 2006, 45, 10973-10980.

514

A. B. Smith, III, M. Xian, and W.-S. Kim. The [1,5]-Brook Rearrangement: An Initial Application in Anion Relay Chemistry. J. Am. Chem. Soc. 2006, 128, 12368-12369.

513

P. J. Stephens, D. M. McCann, F. J. Devlin, and A. B. Smith, III. Determination of the Absolute Configurations of Natural Products via Density Functional Theory Calculations of Optical Rotation, Electronic Circular Dichroism and Vibrational Circular Dichroism: the Cytotoxic Sesqquiterpene Natural Products Quadrone, Subersenone, Suberosanone and Suberosenol A Acetate. J. Nat. Prod. 2006, 69 1055-1064.

512

A. B. Smith, III and V. Simov. Total Synthesis of the Marine Natural Product (–)-Clavosolide A. A Showcase for the Petasis-Ferrier Union/Rearrangement Tactic. Org. Lett. 2006, 8, 3315-3318.

511

A. B. Smith, III, L. Kurti, and A. H. Davulcu. A New Modular Indole Synthesis. Construction of the Highly Strained CDEF Parent Tetracycle of Nodulisporic Acids A and B. Org. Lett. 2006, 8, 2167-2170.

510

A. B. Smith, III, A. H. Davulcu, and L. Kurti. Indole Diterpenoid Synthetic Studies. Construction of the Heptacyclic Core of (-)-Nodulisporic Acid D. Org. Lett. 2006, 8, 1699-1672.

509

A. B. Smith, III, A. H. Davulcu, and L. Kurti. Indole Diterpenoid Synthetic Studies. The Total Synthesis of (+)-Nodulisporic Acid F. Org. Lett. 2006, 8, 1665-1668.

508

A. B. Smith, III, and D.-S. Kim. A General, Convergent Strategy for the Construction of Indolizidine Alkaloids: Total Synthesis of (-)- Indolizidine 223AB and Alkaloid (-)-205B. J. Org. Chem. 2006, 71, 2547-2557.

507

A. B. Smith, III, E. F. Mesaros, and E. A. Meyer. Evolution of a Total Synthesis of (-)-Kendomycin Exploiting a Petasis-Ferrier Rearrangement/Ring-Closing Olefin Metathesis Strategy. J. Am. Chem Soc. 2006, 128, 5292-5299.

506

S. Foister, L. L. Taylor, J.-J. Feng, W.-L. Chen, A. Lin, F.-C. Cheng, A. B. Smith, III, and R. F. Hirschmann. Design and Synthesis of a Potent Cystine-Free Cyclic Hexapeptide Agonist at the Human Urotensin Receptor. Org. Lett. 2006, 7, 1799-1802.

505

A. B.Smith, III, T. M. Razler, R. M. Meis, and G. R. Pettit. The Design and Synthesis of a Potent Phorboxazole C(11-15) Acetal Analogue. Org. Lett. 2006, 7, 797-799.

504

G. S. Hung, L. Lopez-Barcons, R. Perez-Soler, B. S. Freeze, A. B. Snith, III, G. L. Goldberg, S. B. Horowitz, and H. McDaid. Potentiation of Taxol Efficacy by Discodermolide in Ovarian Carcinoma Xenograft-bearing Mice. Clin. Cancer Res. 2006, 12, 298-304.

503

A. B. Smith, III, and M. Xian. Anion Relay Chemistry: An Effective Tactic for Diversity Oriented Synthesis. J. Am. Chem. Soc. 2006, 128, 66-67.

502

A. B. smith, A. K. Charnley, H. Harada, J. J. Beiger, L.-D. Cantin, C.S. Kenesky, R. Hirschmann, S. Munshi, D. B. Olsen, M. W. Stahlhut, W. A. Schleif, and L. C. Kuo. Design, Synthesis and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors Possessing Augmented P2 Side-Chains. Bioorg. Med. Chem. Lett. 2006, 16, 859-863.

501

A. B. Smith, III, J. J. Beiger, A. H. Davulcu, and J. M. Cox. Preparation of [1-(methoxymethylcarbamoyl)ethyl]phosphonic acid bis(2,2,2-trifluoroethyl) ester: A useful intermediate in the synthesis of Z-unsaturated N-methoxy-N-methylamides. Org. Syn. 2005, 82, 147-156.

500

S. Mani, H. Huang, S. Sandarababu, W. Liu, G. Kalpana, A. B. Smith, III, and S. B. Horowitz. Activation of the Steriod and Xenobiotic Receptor (hPXR or SXR) by Non-Taxane Microtubule Stabilizing Agents. Clin. Cancer Res. 2005, 11, 6359-6369.

499

Smith, Amos B., III; Xian, Ming. Design, Synthesis, and Biological Evaluation of Simplified Analogues of (+)-Discodermolide. Additional Insights on the Importance of the Diene, the C(7) Hydroxyl, and the Lactone. Organic Letters (2005), 7(23), 5229-5232.

498

S.Sun, S.E. Aspland, C. Ballatore, R. Castillo, A.B. Smith, III, and A.J. Castelino. The Design and Synthesis and Evaluation of Two Universal Doxorubicin-Linkers. Preparation of Conjugates that Retain Topiisomerase II Activity. Bioorg. Med. Chem. Lett. 2005, 16, 104-107.

497

Smith, Amos B., III; Rucker, Paul V.; Brouard, Ignacio; Freeze, B. Scott; Xia, Shujun; Horwitz, Susan Band. Design, Synthesis, and Biological Evaluation of Potent Discodermolide Fluorescent and Photoaffinity Molecular Probes. Organic Letters (2005), 7(23), 5199-5202.

495

Smith, Amos B., III; Han, Qiang; Breslin, Paul A. S.; Beauchamp, Gary K. Synthesis and Assignment of Absolute Configuration of (-)-Oleocanthal: A Potent, Naturally Occurring Non-steroidal Anti-inflammatory and Anti-oxidant Agent Derived from Extra Virgin Olive Oils. Organic Letters (2005), 7(22), 5075-5078.

494

Smith, Amos B., III; Xian, Ming; Liu, Fenghua. Design, Total Synthesis, and Evaluation of C(13)-C(14) Cyclopropane Analogues of (+)-Discodermolide. Organic Letters (2005), 7(21), 4613-4616.

493

Fuertes, Michael J.; Kaur, Jaskiran; Deb, Prasant; Cooperman, Barry S.; Smith, Amos B.. Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase. Bioorganic & Medicinal Chemistry Letters (2005), 15(23), 5146-5149.

492

Smith, Amos B., III; Razler, Thomas M.; Ciavarri, Jeffrey P.; Hirose, Tomoyasu; Ishikawa, Tomoyasu. (+)-Phorboxazole A Synthetic Studies. A Highly Convergent, Second Generation Total Synthesis of (+)-Phorboxazole A. Organic Letters (2005), 7(20), 4399-4402.

491

Smith, Amos B., III; Razler, Thomas M.; Pettit, George R.; Chapuis, Jean-Charles. (+)-Phorboxazole A Synthetic Studies. Identification of a Series of Highly Cytotoxic C(45-46) Analogues. Organic Letters (2005), 7(20), 4403-4406.

490

Beauchamp, Gary K.; Keast, Russell S. J.; Morel, Diane; Lin, Jianming; Pika, Jana; Han, Qiang; Lee, Chi-Ho; Smith, Amos B.; Breslin, Paul A. S. Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil. Nature (London, United Kingdom) (2005), 437(7055), 45-46.

489

Cho, Cheon-Gyu; Kim, Won-Suk; Smith, Amos B., III. A Scalable Route to Trisubstituted (E)-Vinyl Bromides. Organic Letters (2005), 7(16), 3569-3572. CODEN: ORLEF7 ISSN:1523-7060.

488

Ballatore, Carlo; Aspland, Simon E.; Castillo, Rosario; Desharnais, Joel; Eustaquio, Trisha; Sun, Chengzao; Castellino, Angelo J.; Smith, Amos B.. A facile route to paclitaxel C-10 carbamates. Bioorganic & Medicinal Chemistry Letters (2005), 15(10), 2477-2480.

487

Smith, Amos B., III; Freeze, B. Scott; LaMarche, Matthew J.; Sager, Jason; Kinzler, Kenneth W.; Vogelstein, Bert. Discodermolide analogues as the chemical component of combination bacteriolytic therapy. Bioorganic & Medicinal Chemistry Letters (2005), 15(15), 3623-3626.

486

Neelamkavil, Santhosh; Arison, Byron; Birzin, Elizabeth; Feng, Jin-Jye; Chen, Kuo-Hsin; Lin, Atsui; Cheng, Fong-Chi; Taylor, Laurie; Thornton, Edward R.; Smith, Amos B., III; Hirschmann, Ralph. Replacement of Phe6, Phe7, and Phe11 of D-Trp8-Somatostatin-14 with L-Pyrazinylalanine. Predicted and Observed Effects on Binding Affinities at hSST2 and hSST4. An Unexpected Effect of the Chirality of Trp8 on NMR Spectra in Methanol. Journal of Medicinal Chemistry (2005), 48(12), 4025-4030.

485

Smith, Amos B., III; Kim, Dae-Shik. Total Synthesis of the Neotropical Poison-Frog Alkaloid (-)-205B. Organic Letters (2005), 7(15), 3247-3250.

484

Smith, Amos B., III; Fox, Richard J.; Vanecko, John A. (+)-Sorangicin A Synthetic Studies. Construction of the C(1-15) and C(16-29) Subtargets. Organic Letters (2005), 7(14), 3099-3102.

483

J.Q. Trojanovsky, A.B. Smith, III, D. Huryn, and M.-Y. Lee. Microtubule Stabilizing Drugs for Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders With Axonal Transport Impairments. Expert Opin. Pharmacother. 2005, 6, 683-685

482

Klein Laura E; Freeze B Scott; Smith Amos B 3rd; Horwitz Susan Band The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell cycle (Georgetown, Tex.) (2005), 4(3), 501-7.

481

Sunazuka, Toshiaki; Hirose, Tomoyasu; Chikaraishi, Noriko; Harigaya, Yoshihiro; Hayashi, Masahiko; Komiyama, Kanki; Sprengeler, Paul A.; Smith, Amos B.; Omura, Satoshi. Absolute stereochemistries and total synthesis of (+)/(-)-macrosphelides, potent, orally bioavailable inhibitors of cell-cell adhesion. Tetrahedron (2005), 61(15), 3789-3803.

480

Smith, Amos B., III; Mesaros, Eugen F.; Meyer, Emmanuel A. Total Synthesis of (-)-Kendomycin Exploiting a Petasis-Ferrier Rearrangement/Ring-Closing Olefin Metathesis Synthetic Strategy. Journal of the American Chemical Society (2005), 127(19), 6948-6949.

479

Shaw, Simon J.; Sundermann, Kurt F.; Burlingame, Mark A.; Myles, David C.; Freeze, B. Scott; Xian, Ming; Brouard, Ignacio; Smith, Amos B., III. Toward Understanding How the Lactone Moiety of Discodermolide Affects Activity. Journal of the American Chemical Society (2005), 127(18), 6532-6533.

478

Smith, Amos B., III; Freeze, B. Scott; Xian, Ming; Hirose, Tomoyasu. Total Synthesis of (+)-Discodermolide: A Highly Convergent Fourth-Generation Approach. Organic Letters (2005), 7(9), 1825-1828.

477

Angeles, Angie R.; Neagu, Irina; Birzin, Elizabeth T.; Thornton, Edward R.; Smith, Amos B., III; Hirschmann, Ralph. Synthesis and Binding Affinities of Novel SRIF-Mimicking b-D-Glucosides Satisfying the Requirement for a p-Cloud at C1. Organic Letters (2005), 7(6), 1121-1124.

476

Neelamkavil, S.; Mowery, B. P.; Thornton, E. R.; Smith, A. B., III; Hirschmann, R. A practical synthesis of Na-Fmoc-L-pyrazinylalanine via Schoellkopf's chiral auxiliary. Journal of Peptide Research (2005), 65(1), 139-142.

475

Smith, Amos B., III; Charnley, Adam K.; Mesaros, Eugen F.; Kikuchi, Osamu; Wang, Wenyong; Benowitz, Andrew; Chu, Chi-Lien; Feng, Jin-Jye; Chen, Kuo-Hsin; Lin, Atsui; Cheng, Fong-Chi; Taylor, Laurie; Hirschmann, Ralph. Design, Synthesis, and Binding Affinities of Pyrrolinone-Based Somatostatin Mimetics. Organic Letters (2005), 7(3), 399-402.

474

Smith, Amos B., III; Freeze, B. Scott; LaMarche, Matthew J.; Hirose, Tomoyasu; Brouard, Ignacio; Rucker, Paul V.; Xian, Ming; Sundermann, Kurt F.; Shaw, Simon J.; Burlingame, Mark A.; Horwitz, Susan Band; Myles, David C. Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide. Organic Letters (2005), 7(2), 311-314.

473

472

Smith, Amos B., III; Walsh, Shawn P.; Frohn, Michael; Duffey, Matthew O. Diversity-Oriented Synthesis of Polyketide Natural Products via Iterative Chemo- and Stereoselective Functionalization of Polyenoates: Development of a Unified Approach for the C(1-19) Segments of Lituarines A-C. Organic Letters (2005), 7(1), 139-142.

471

Smith, Amos B., III. Editorial 2005. Organic Letters (2005), 7(1), 1-2.

470

Smith, Amos B., III; Sfouggatakis, Chris; Gotchev, Dimitar B.; Shirakami, Shohei; Bauer, David; Zhu, Wenyu; Doughty, Victoria A. Spongistatin Synthetic Studies. Evolution of a Scalable Synthesis for the EF Fragment of (+)-Spongistatin 1 Exploiting a Petasis-Ferrier Union/Rearrangement Tactic. Organic Letters (2004), 6(20), 3637-3640.

469

ang, Jiangyong; Mei, Erwen; Green, Clive; Kaplan, Justin; DeGrado, William F.; Smith, Amos B., III; Hochstrasser, Robin M. Probing structural dynamics of individual calmodulin: peptide complexes in hydrogels by single-molecule confocal microscopy. Journal of Physical Chemistry B (2004), 108(40), 15910-15918.

468

Smith, Amos B., III; Adams, Christopher M.; Barbosa Lodise, Stephanie A.; Degnan, Andrew P.. A unified approach to the tedanolides: Total synthesis of (+)-13-deoxytedanolide. Proceedings of the National Academy of Sciences of the United States of America (2004), 101(33), 12042-12047.

467

Smith, Amos B., III; Duffey, Matthew O.. Bifunctional molecular linchpins: A three-component coupling protocol employing 2-bromoallyltrimethylsilane. Synlett (2004), (8), 1363-1366.

466

Fang, C.; Wang, J.; Kim, Y. S.; Charnley, A. K.; Barber-Armstrong, W.; Smith, A. B., III; Decatur, S. M.; Hochstrasser, R. M. Two-Dimensional Infrared Spectroscopy of Isotopomers of an Alanine Rich a-Helix. Journal of Physical Chemistry B (2004), 108(29), 10415-10427.

465

Dang, Long H.; Bettegowda, Chetan; Agrawal, Nishant; Cheong, Ian; Huso, David; Frost, Philip; Loganzo, Frank; Greenberger, Lee; Barkoczy, Jozsef; Pettit, George R.; Smith, Amos B., III; Gurulingappa, Hallur; Khan, Saeed; Kinzler, Kenneth W.; Zhou, Shibin; Vogelstein, Bert. Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents. Cancer Biology & Therapy (2004), 3(3), 326-337.

464

Smith, Amos B., III; Adams, Christopher M. Evolution of Dithiane-Based Strategies for the Construction of Architecturally Complex Natural Products. Accounts of Chemical Research (2004), 37(6), 365-377.

463

A.B. Smith, III, and S.M. Pitram. 2-tetra-Butyldimethylsilyl-1,3-dithiane. Electronic Encyclopedia of Reagents for Organic Synthesis, ed. L. Paquette, P. Fuchs, D. Crich, and P. Wipf.

462

Burlingame, Mark A.; Shaw, Simon J.; Sundermann, Kurt F.; Zhang, Dan; Petryka, Joseph; Mendoza, Esteban; Liu, Fenghua; Myles, David C.; LaMarche, Matthew J.; Hirose, Tomoyasu; Freeze, B. Scott; Smith, Amos B. Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues. Bioorganic & Medicinal Chemistry Letters (2004), 14(9), 2335-2338.

461

Madani, Navid; Perdigoto, Ana Luisa; Srinivasan, Kumar; Cox, Jason M.; Chruma, Jason J.; LaLonde, Judith; Head, Martha; Smith, Amos B., III; Sodroski, Joseph G. Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155.Journal of Virology (2004), 78(7), 3742-3752.

460

Si, Zhihai; Madani, Navid; Cox, Jason M.; Chruma, Jason J.; Klein, Jeffrey C.; Schoen, Arne; Phan, Ngoc; Wang, Liping; Biorn, Alyssa C.; Cocklin, Simon; Chaiken, Irwin; Freire, Ernesto; Smith, Amos B., III; Sodroski, Joseph G. Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins. Proceedings of the National Academy of Sciences of the United States of America (2004), 101(14), 5036-5041.

459

Smith, Amos B., III; Kim, Dae-Shik. Multicomponent Linchpin Coupling of Silyl Dithianes Employing an N-Ts Aziridine as the Second Electrophile: Synthesis of (-)-Indolizidine 223AB. Organic Letters (2004), 6(9), 1493-1495.

458

Smith, Amos B., III; Fox, Richard J. Construction of a C(30-38) Dioxabicyclo[3.2.1]octane Subtarget for (+)-Sorangicin A, Exploiting a Regio- and Stereocontrolled Acid-Catalyzed Epoxide Ring Opening. Organic Letters (2004), 6(9), 1477-1480.

457

Smith, Amos B.; Chruma, Jason J.; Han, Qiang; Barbosa, Joseph. Complestatin synthetic studies: the effect of the amino acid configuration on peptide backbone conformation in the common western BCD macrocycle. Bioorganic & Medicinal Chemistry Letters (2004), 14(7), 1697-1702.

456

Abrous, Leiela; Jokiel, Patrick A.; Friedrich, Sarah R.; Hynes, John, Jr.; Smith, Amos B., III; Hirschmann, Ralph. Novel Chimeric Scaffolds to Extend the Exploration of Receptor Space: Hybrid b-D-Glucose-Benzoheterodiazepine Structures for Broad Screening. Effect of Amide Alkylation on the Course of Cyclization Reactions. Journal of Organic Chemistry (2004), 69(2), 280-302.

455

Smith, Amos B., III. The next five years. Organic Letters (2004), 6(1), 1-2.

454

Fang, C.; Wang, J.; Charnley, A. K.; Barber-Armstrong, W.; Smith, A. B.; Decatur, S. M.; Hochstrasser, R. M. Two-dimensional infrared measurements of the coupling between amide modes of an a-helix. Chemical Physics Letters (2003), 382(5,6), 586-592.

453

Smith, Amos B., III; Hirschmann, Ralph. Search for Biologically Active Peptidomimetics of beta-turns and beta-starnds. Designed Scaffolds and Serendipitious Observations. Peotide Revolution: Genomics, Proteomics & Therapeutics. Eds. M. Chorev and T.K. Sawyer. American Peptide Society, 2003.

452

Smith, Amos B., III; Cui, Haifeng. Indole-diterpene synthetic studies: Total synthesis of (-)-21-isopentenylpaxilline. Helvetica Chimica Acta (2003), 86(12), 3908-3938.

451

Smith, Amos B.; Freeze, B. Scott; Brouard, Ignacio; Hirose, Tomoyasu. A Practical Improvement, Enhancing the Large-Scale Synthesis of (+)-Discodermolide: A Third-Generation Approach. Organic Letters (2003), 5 (23), 4405-4408.

450

Sulfur. Smith, Amos B., III. Chemical & Engineering News (2003), 81(36), 60.

449

Smith, Amos B.; Pitram, Suresh M.; Boldi, Armen M.; Gaunt, Matthew J.; Sfouggatakis, Chris; Moser, William H. Multicomponent Linchpin Couplings. Reaction of Dithiane Anions with Terminal Epoxides, Epichlorohydrin, and Vinyl Epoxides: Efficient, Rapid, and Stereocontrolled Assembly of Advanced Fragments for Complex Molecule Synthesis. Journal of the American Chemical Society (2003), 125 (47), 14435-14445.

448

Smith, Amos B.; Pitram, Suresh M.; Fuertes, Michael J. (+)-Rimocidin Synthetic Studies. Construction of an Advanced C(1-18) Polyol Fragment. Organic Letters (2003), 5 (15), 2751-2754.

447

Smith, Amos B.; Cho, Young Shin; Pettit, G. Robert; Hirschmann, Ralph. Design, synthesis, and evaluation of azepine-based cryptophycin mimetics. Tetrahedron (2003), 59 (35), 6991-7009.

446

Smith, Amos B.; Kanoh, Naoki; Ishiyama, Haruaki; Minakawa, Noriaki; Rainier, Jon D.; Hartz, Richard A.; Cho, Young Shin; Cui, Haifeng; Moser, William H. Tremorgenic Indole Alkaloids. The Total Synthesis of (-)-Penitrem D. Journal of the American Chemical Society (2003), 125 (27), 8228-8237.

445

Prasad, Vidya; Birzin, Elizabeth T.; McVaugh, Cheryl T.; van Rijn, Rachel D.; Rohrer, Susan P.; Chicchi, Gary; Underwood, Dennis J.; Thornton, Edward R.; Smith, Amos B., III; Hirschmann, Ralph. Effects of Heterocyclic Aromatic Substituents on Binding Affinities at Two Distinct Sites of Somatostatin Receptors. Correlation with the Electrostatic Potential of the Substituents. Journal of Medicinal Chemistry (2003), 46(10), 1858-1869

444

Smith, Amos B., III; Cantin, Louis-David; Pasternak, Alexander; Guise-Zawacki, Lisa; Yao, Wenquin; Charnley, Adam K.; Barbosa, Joseph; Sprengeler, Paul A.; Hirschmann, Ralph; Munshi, Sanjeev; Olsen, David B.; Schleif, William A.; Kuo, Lawrence C. Design, Synthesis, and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors. Journal of Medicinal Chemistry (2003), 46(10), 1831-1844.

443

Savinov, Sergey N.; Hirschmann, Ralph; Benkovic, Stephen J.; Smith, Amos B. Investigation of an antibody-ligase. evidence for strain-induced catalysis. Bioorganic & Medicinal Chemistry Letters (2003), 13(7), 1321-1324

442

Murphy, Paul V.; O'Brien, Julie L.; Gorey-Feret, Lorraine J.; Smith, Amos B. Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds. Tetrahedron (2003), 59(13), 2259-2271.

441

Smith, Amos B., III; Zhu, Wenyu; Shirakami, Shohei; Sfouggatakis, Chris; Doughty, Victoria A.; Bennett, Clay S.; Sakamoto, Yasuharu. Total Synthesis of (+)-Spongistatin 1. An Effective Second-Generation Construction of an Advanced EF Wittig Salt, Fragment Union, and Final Elaboration. Organic Letters (2003), 5(5), 761-764.

440

Smith, Amos B.; Cui, Haifeng. Total Synthesis of (-)-21-Isopentenylpaxilline. Organic Letters (2003), 5(4), 587-590.

439

Smith, Amos B.; Adams, Christopher M.; Barbosa, Stephanie A. Lodise; Degnan, Andrew P. Total Synthesis of (+)-13-Deoxytedanolide. Journal of the American Chemical Society (2003), 125(2), 350-351.

438

Smith, Amos B.. Editorial 2003: Year Four. Organic Letters (2003), 5(1), 1-2.

437

Smith, Amos B., III; Pitram, Suresh M.; Gaunt, Matthew J.; Kozmin, Sergey A. Dithiane Additions to Vinyl Epoxides: Steric Control over the SN2 and SN2' Manifolds Journal of the American Chemical Society (2002), 124(49), 14516-14517.

436

Smith, Amos B.; Lee, Dongjoo; Adams, Christopher M.; Kozlowski, Marisa C. SmI2-Promoted Oxidation of Aldehydes in the Presence of Electron-Rich Heteroatoms. Organic Letters (2002), 4(25), 4539-4541.

435

Smith, Amos B., III; Savinov, Sergey N.; Manjappara, Uma V.; Chaiken, Irwin M. Peptide-small molecule hybrids via orthogonal deprotection-chemoselective conjugation to cysteine-anchored scaffolds. A model study. Organic Letters (2002), 4(23), 4041-4044.

434

Smith, Amos B.; Safonov, Igor G.; Corbett, R. Michael. Total Syntheses of (+)-Zampanolide and (+)-Dactylolide Exploiting a Unified Strategy. Journal of the American Chemical Society (2002), 124(37), 11102-11113.

433

Smith, Amos B.; Zheng, Junying. Total synthesis of (-)-salicylihalamide A and related congeners. Tetrahedron (2002), 58(32), 6455-6471.

432

Smith, Amos B.; Corbett, R. Michael; Pettit, George R.; Chapuis, Jean-Charles; Schmidt, Jean M.; Hamel, Ernest; Jung, M. Katherine. Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue. Bioorganic & Medicinal Chemistry Letters (2002), 12(15), 2039-2042.

431

P.V. Murphy, J.L. O'Brien, L.J. Gorey-Feret, and A.B. Smith, III. Structure-Based Design and Synthesis of HIV-1 Protease Inhibitors Employing b-D-Mannopyranoside Scaffolds. Bioorg. Med.Chem. Lett. 2002, 12, 1763-1766

430

Smith, Amos B., III; Doughty, Victoria A.; Sfouggatakis, Chris; Bennett, Clay S.; Koyanagi, Jyunichi; Takeuchi, Makoto. Spongistatin Synthetic Studies. An Efficient, Second-Generation Construction of an Advanced ABCD Intermediate. Organic Letters (2002), 4(5), 783-786.

429

Smith, Amos B., III; Safonov, Igor G. Total Synthesis of (+)-Dactylolide. Organic Letters (2002), 4(4), 635-637.

428

Smith, Amos B., III. Editorial: the first three years. Organic Letters (2002), 4(1), 1.

427

Smith, Amos B., III; Cho, Young Shin; Zawacki, Lisa E.; Hirschmann, Ralph; Pettit, George R. First Generation Design, Synthesis, and Evaluation of Azepine-Based Cryptophycin Analogues. Organic Letters (2001), 3(25), 4063-4066.

426

Smith, Amos B., III; Frohn, Michael. Lituarine Synthetic Studies. An Efficient, Stereocontrolled Construction of the Common C(7-19) Tricyclic Spiroketal Fragment. Organic Letters (2001), 3(24), 3979-3982.

425

Smith, Amos B., III; Cho, Young Shin; Ishiyama, Haruaki. Nodulisporic Acid A Synthetic Studies. 2. Construction of an Eastern Hemisphere Subtarget. Organic Letters (2001), 3(24), 3971-3974.

424

Smith, Amos B., III; Ishiyama, Haruaki; Cho, Young Shin; Ohmoto, Kazuyuki. Nodulisporic Acid A Synthetic Studies. 1. Overall Strategy and Construction of a Western Hemisphere Subtarget. Organic Letters (2001), 3(24), 3967-3970.

423

Smith, Amos B., III; Safonov, Igor G.; Corbett, R. Michael. Total Synthesis of (+)-Zampanolide. Journal of the American Chemical Society (2001), 123(49), 12426-12427.

422

P.V. Murphy, J.L. O'Brien, and A.B. Smith, III. Stereospecific syntheses of b-D-allopyranosides by dihydroxylation of b-D-erythro-2,3-dideoxyhex-2-enopyranosides. Carbohydr. Res. 2001, 334, 327-335

421

Smith, Amos B., III; Minbiole, Kevin P.; Freeze, Scott. Facile assembly of 2,4-orthogonally-functionalized oxazoles: useful bidirectional linchpins. Synlett (2001), (11), 1739-1742.

420

Smith, Amos B., III; Minbiole, Kevin P.; Verhoest, Patrick R.; Schelhaas, Michael. Total synthesis of (+)-phorboxazole A exploiting the Petasis-Ferrier rearrangement. Journal of the American Chemical Society (2001), 123(44), 10942-10953.

419

Martello, L. A.; LaMarche, M. J.; He, L.; Beauchamp, T. J.; Smith, A. B.; Horwitz, S. B. The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. Chemistry & Biology (2001), 8(9), 843-855.

418

417. S. B. Horwitz, L. A. Martello, C.- P. H. Yang, A. B. Smith, III, and H. M. McDaid, "Discodermolide and Taxol: A Synergistic Drug Combination in Human Carcinoma Cell Lines" In Anticancer Agents: Frontiers in Cancer Chemotherapy, Ojima, I.; Vite, G. D.; Karh-Heinz Altmann, K.-H. (eds.); ACS Symp. Series 796, American Chemical Society, Washington, D. C., 2001; pp 81-96.

417

Smith, Amos B., III; Adams, Christopher M.; Kozmin, Sergey A.; Paone, Daniel V. Total Synthesis of (-)-Cylindrocyclophanes A and F Exploiting the Reversible Nature of the Olefin Cross Metathesis Reaction. Journal of the American Chemical Society (2001), 123(25), 5925-5937.

416

Smith, Amos B., III; Zheng, Junying. A first generation total synthesis of (+)-salicylihalamide A. Synlett (2001), (Spec. Issue), 1019-1023.

415

Smith, Amos B., III; Brandt, Benjamin M. Total Synthesis of (-)-Callystatin A. Organic Letters (2001), 3(11), 1685-1688.

414

Smith, Amos B., III; Verhoest, Patrick R.; Minbiole, Kevin P.; Schelhaas, Michael. Total Synthesis of (+)-Phorboxazole A. Journal of the American Chemical Society (2001), 123(20), 4834-4836.

413

Abrous, Leiela; Hynes, John, Jr.; Friedrich, Sarah R.; Smith, Amos B., III; Hirschmann, Ralph. Design and Synthesis of Novel Scaffolds for Drug Discovery: Hybrids of b-D-Glucose with 1,2,3,4-Tetrahydrobenzo[e][1,4]diazepin-5-one, the Corresponding 1-Oxazepine, and 2- and 4-Pyridyldiazepines. Organic Letters (2001), 3(7), 1089-1092.

412

Smith, Amos B., III; LaMarche, Matthew J.; Falcone-Hindley, Margaret. Solution Structure of (+)-Discodermolide. Organic Letters (2001), 3(5), 695-698.

411

Smith, Amos B., III; Adams, Christopher M.; Kozmin, Sergey A. On the Reversible Nature of the Olefin Cross Metathesis Reaction. Journal of the American Chemical Society (2001), 123(5), 990-991.

410

Smith, Amos B., III; Lin, Qiyan; Doughty, Victoria A.; Zhuang, Linghang; McBriar, Mark D.; Kerns, Jeffrey K.; Brook, Christopher S.; Murase, Noriaki; Nakayama, Kiyoshi. The spongistatins: architecturally complex natural products. Part two. Synthesis of the C(29-51) subunit, fragment assembly, and final elaboration to (+)-spongistatin 2. Angewandte Chemie, International Edition (2001), 40(1), 196-199.

409

Smith, Amos B., III; Doughty, Victoria A.; Lin, Qiyan; Zhuang, Linghang; McBriar, Mark D.; Boldi, Armen M.; Moser, William H.; Murase, Noriaki; Nakayama, Kiyoshi; Sobukawa, Masao. The spongistatins: architecturally complex natural products - Part one: a formal synthesis of (+)-spongistatin 1 by construction of an advanced ABCD fragment. Angewandte Chemie, International Edition (2001), 40(1), 191-195.

408

Hirschmann, Ralph; Ducry, Laurent; Smith, Amos B., III. Development of an Efficient, Regio- and Stereoselective Route to Libraries Based on the b-D-Glucose Scaffold. Journal of Organic Chemistry (2000), 65(24), 8307-8316.

407

Smith, Amos B., III; Ducry, Laurent; Corbett, R. Michael; Hirschmann, Ralph. Intramolecular Hydrogen-Bond Participation in Phosphonylammonium Salt Formation. Organic Letters (2000), 2(24), 3887-3890.

406

Rainier, J. D.; Smith, A. B.. Polyene cyclizations to indole diterpenes. The first synthesis of (+)-emindole SA using a biomimetic approach. Tetrahedron Letters (2000), 41(49), 9419-9423.

405

Smith, Amos B., III; Nittoli, Thomas; Sprengeler, Paul A.; Duan, James J.-W.; Liu, Rui-Qin; Hirschmann, Ralph F. Design, Synthesis, and Evaluation of a Pyrrolinone-Based Matrix Metalloprotease Inhibitor. Organic Letters (2000), 2(24), 3809-3812.

404

Liu, Josephine; Underwood, Dennis J.; Cascieri, Margaret A.; Rohrer, Susan P.; Cantin, Louis-David; Chicchi, Gary; Smith, Amos B., III; Hirschmann, Ralph. Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry. Journal of Medicinal Chemistry (2000), 43(21), 3827-3831.

403

Smith, Amos B., III; Kanoh, Naoki; Ishiyama, Haruaki; Hartz, Richard A. Total Synthesis of (-)-Penitrem D. Journal of the American Chemical Society (2000), 122(45), 11254-11255.

402

Smith, Amos B., III; Wang, Wenyong; Sprengeler, Paul A.; Hirschmann, Ralph. Design, Synthesis, and Solution Structure of a Pyrrolinone-Based b-Turn Peptidomimetic. Journal of the American Chemical Society (2000), 122(44), 11037-11038.

401

Stetzer, M. R.; Heiney, P. A.; Stephens, P. W.; Dinnebier, R. E.; Zhu, Q.; McGhie, A. R.; Strongin, R. M.; Brandt, B. M.; Smith, A. B., III. Structure and phase transitions of the 6,6-cyclopropane isomer of C61H2. Physical Review B: Condensed Matter and Materials Physics (2000), 62(14), 9305-9316.

400

Smith, Amos B., III; Beauchamp, Thomas J.; LaMarche, Matthew J.; Kaufman, Michael D.; Qiu, Yuping; Arimoto, Hirokazu; Jones, David R.; Kobayashi, Kaoru. Evolution of a Gram-Scale Synthesis of (+)-Discodermolide. Journal of the American Chemical Society (2000), 122(36), 8654-8664.

399

Lee, Kon Ho; Olson, Gary L.; Bolin, David R.; Benowitz, Andrew B.; Sprengeler, Paul A.; Smith, Amos B., III; Hirschmann, Ralph F.; Wiley, Don C. The Crystal Structure of a Pyrrolinone-Peptide Hybrid Ligand Bound to the Human Class II MHC Protein HLA-DR1. Journal of the American Chemical Society (2000), 122(35), 8370-8375.

398

Smith, A. B., III; Org. Lett.; (Editorial); 2000; 2(1); 1-2.

397

Smith, Amos B. ,III; Liu, Hu; Okumura, Hiroyuki; Favor, David A.; Hirschmann, Ralph. Synthesis of Polypyrrolinones on Solid Support. Organic Letters (2000), 2(14), 2041-2044.

396

Smith, Amos B., III; Liu, Hu; Hirschmann, Ralph. A Second-Generation Synthesis of Polypyrrolinone Nonpeptidomimetics: Prelude to the Synthesis of Polypyrrolinones on Solid Support. Organic Letters (2000), 2(14), 2037-2040.

395

Kondru, Rama K.; Beratan, David N.; Friestad, Gregory K.; Smith, Amos B., III; Wipf, Peter. Chiral Action at a Distance: Remote Substituent Effects on the Optical Activity of Calyculins A and B. Organic Letters (2000), 2(11), 1509-1512.

394

Smith, Amos B., III; Wan, Zehong. Total Synthesis of the Ansamycin Antibiotic (+)-Thiazinotrienomycin E. Journal of Organic Chemistry (2000), 65(12), 3738-3753.

393

Martello, Laura A.; McDaid, Hayley M.; Regl, Donna Lee; Yang, Chia-Ping H.; Meng, Dongfang; Pettus, Thomas R. R.; Kaufman, Michael D.; Arimoto, Hirokazu; Danishefsky, Samuel J.; Smith, Amos B., III; Horwitz, Susan Band. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clinical Cancer Research (2000), 6(5), 1978-1987.

392

Smith, Amos B. III; Kozmin, Sergey A.; Adams, Christopher M.; Paone, Daniel V. Assembly of (-)-Cylindrocyclophanes A and F via Remarkable Olefin Metathesis Dimerizations. Journal of the American Chemical Society (2000), 122(20), 4984-4985.

391

Smith, Amos B., III; Sestelo, Jose Perez; Dormer, Peter G. A highly efficient synthetic route to (-)-furaquinocin C. Heterocycles (2000), 52(3), 1315-1328.

390

Sunazuka, Toshiaki; Hirose, Tomoyasu; Shirahata, Tatsuya; Harigaya, Yoshihiro; Hayashi, Masahiko; Komiyama, Kanki; Omura, Satoshi; Smith, Amos B., III. Total Synthesis of (+)-Madindoline A and (-)-Madindoline B, Potent, Selective Inhibitors of Interleukin 6. Determination of the Relative and Absolute Configurations. Journal of the American Chemical Society (2000), 122(9), 2122-2123.

389

Smithrud, David B.; Benkovic, Patricia A.; Benkovic, Stephen J.; Roberts, Victoria; Liu, Josephine; Neagu, Irina; Iwama, Seiji; Phillips, Barton W.; Smith, Amos B.; Hirschmann, Ralph. Cyclic peptide formation catalyzed by an antibody ligase. Proceedings of the National Academy of Sciences of the United States of America (2000), 97(5), 1953-1958.

388

Schiller, Peter W.; Berezowska, Irena; Nguyen, Thi M.-D.; Schmidt, Ralf; Lemieux, Carole; Chung, Nga N.; Falcone-Hindley, Margaret L.; Yao, Wenqing; Liu, Josephine; Iwama, Seiji; Smith, Amos B., III; Hirschmann, Ralph. Novel Ligands Lacking a Positive Charge for the d- and m-Opioid Receptors. Journal of Medicinal Chemistry (2000), 43(4), 551-559.

387

Amith, Amos B., III. Organic Letters - Editorial 2000. Organic Letters (2000), 2(1), 1-2.

386

Smith, Amos B., III; Pitram, Suresh M. Multicomponent Linchpin Couplings of Silyl Dithianes: Synthesis of the Schreiber C(16-28) Trisacetonide Subtarget for Mycoticins A and B. Organic Letters (1999), 1(12), 2001-2004.

385

Smith, Amos B., III; Empfield, James R. Synthetic strategies towards the total synthesis of phyllanthocin and breynolide. Application of stereochemically linear and convergent strategies. Chemical & Pharmaceutical Bulletin (1999), 47(12), 1671-1678.

384

Smith, Amos B., III; Friestad, Gregory K.; Barbosa, Joseph; Bertounesque, Emmanuel; Duan, James J.-W.; Hull, Kenneth G.; Iwashima, Makoto; Qiu, Yuping; Spoors, P. Grant; Salvatore, Brian A. Total Synthesis of (+)-Calyculin A and (-)-Calyculin B: Cyanotetraene Construction, Asymmetric Synthesis of the C(26-37) Oxazole, Fragment Assembly, and Final Elaboration. Journal of the American Chemical Society (1999), 121(45), 10478-10486.

383

Smith, Amos B., III; Friestad, Gregory K.; Barbosa, Joseph; Bertounesque, Emmanuel; Hull, Kenneth G.; Iwashima, Makoto; Qiu, Yuping; Salvatore, Brian A.; Spoors, P. Grant; Duan, James J.-W. Total Synthesis of (+)-Calyculin A and (-)-Calyculin B: Asymmetric Synthesis of the C(9-25) Spiroketal Dipropionate Subunit. Journal of the American Chemical Society (1999), 121(45), 10468-10477.

382

Smith, Amos B., III; Kaufman, Michael D.; Beauchamp, Thomas J.; LaMarche, Matthew J.; Arimoto, Hirokazu. Gram-Scale Synthesis of (+)-Discodermolide. Organic Letters (1999), 1(11), 1823-1826.

381

Smith, Amos B., III; Wan, Zehong. Total Synthesis of (+)-Thiazinotrienomycin E. Organic Letters (1999), 1(9), 1491-1494.

380

Smith, Amos B., III; Kanoh, Naoki; Minakawa, Noriaki; Rainier, Jon D.; Blase, Frances R.; Hartz, Richard A. Tremorgenic Indole Alkaloids. Studies Directed toward the Assembly of the A, F, and I Rings of Penitrem D: Observation of an Unexpected Stereochemical Outcome. Organic Letters (1999), 1(8), 1263-1266.

379

Smith, Amos B., III; Benowitz, Andrew B.; Sprengeler, Paul A.; Barbosa, Joseph; Guzman, Mark C.; Hirschmann, Ralph; Schweiger, Edwin J.; Bolin, David R.; Nagy, Zoltan; Campbell, Robert M.; Cox, Donald C.; Olson, Gary L. Design and Synthesis of a Competent Pyrrolinone-Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1. Journal of the American Chemical Society (1999), 121(40), 9286-9298.

378

Smith, Amos B., III; Lodise, Stephanie A. Synthesis of Tedanolide and 13-Deoxytedanolide. Assembly of a Common C(1)-C(11) Subtarget. Organic Letters (1999), 1(8), 1249-1252.

377

Liehr, Sebastian; Barbosa, Joseph; Smith, Amos B., III; Cooperman, Barry S. Synthesis and biological activity of cyclic peptide inhibitors of ribonucleotide reductase. Organic Letters (1999), 1(8), 1201-1204.

376

Smith, Amos B., III; Minbiole, Kevin P.; Verhoest, Patrick R.; Beauchamp, Thomas J. Phorboxazole Synthetic Studies. 2. Construction of a C(20-28) Subtarget, a Further Extension of the Petasis-Ferrier Rearrangement. Organic Letters (1999), 1(6), 913-916.

375

Smith, Amos B., III; Verhoest, Patrick R.; Minbiole, Kevin P.; Lim, John J. Phorboxazole Synthetic Studies. 1. Construction of a C(3-19) Subtarget Exploiting an Extension of the Petasis-Ferrier Rearrangement. Organic Letters (1999), 1(6), 909-912.

374

Heiney, Paul A.; Stetzer, MacKenzie R.; Mindyuk, Oksana Y.; DiMasi, Elaine; McGhie, Andrew R.; Liu, Hu; Smith, Amos B. III. Langmuir Films of Amphiphilic Crown Ethers. Journal of Physical Chemistry B (1999), 103(30), 6206-6214.

373

Smith, III, A. B.; “Editorial”; Org. Lett. 1, 1 (1999).

372

Soli, Eric D.; Manoso, Amy S.; Patterson, Michael C.; DeShong, Philip; Favor, David A.; Hirschmann, Ralph; Smith, Amos B., III. Azide and Cyanide Displacements via Hypervalent Silicate Intermediates. [Erratum to document cited in CA130:296920]. Journal of Organic Chemistry (1999), 64(17), 6526.

371

Smith, Amos B., III; Kozmin, Sergey A.; Paone, Daniel V. Total Synthesis of (-)-Cylindrocyclophane F. Journal of the American Chemical Society (1999), 121(32), 7423-7424.

370

Smith, Amos B., III; Kanoh, Naoki; Minakawa, Noriaki; Rainier, Jon D.; Hartz, Richard A.; Clark, William M.; Haseltine, John N. Total synthesis of penitrem D. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (1999), 41st 55-60.

369

Sunazuka, T.; Hirose, T.; Shirahata, T.; Harigaya, Y.; Hayashi, M.; Komiyama, K.; Smith, A. B., III; Omura, S. Relative and absolute stereochemistries and total syntheses of madindolines A and B, potent, selective inhibitors of IL-6 activity. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (1999), 41st 49-54.

368

Smith, Amos B., III; Favor, David A.; Sprengeler, Paul A.; Guzman, Mark C.; Carroll, Patrick J.; Furst, George T.; Hirschmann, Ralph. Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold. Bioorganic & Medicinal Chemistry (1999), 7(1), 9-22.

367

Smith, Amos B., III; Sasho, Setsuya; Barwis, Bari A.; Sprengeler, Paul; Barbosa, Joseph; Hirschmann, Ralph; Cooperman, Barry S. Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase. Bioorganic & Medicinal Chemistry Letters (1998), 8(22), 3133-3136.

366

Smith, Amos B., III; Cho, Young Shin; Friestad, Gregory K. Convenient Wacker oxidations with substoichiometric cupric acetate. Tetrahedron Letters (1998), 39(48), 8765-8768.

365

Smith, Amos B. ,III; Benowitz, Andrew B.; Guzman, Mark C.; Sprengeler, Paul A.; Hirschmann, Ralph; Schweiger, Edwin J.; Bolin, David R.; Nagy, Zoltan; Campbell, Robert M.; Cox, Donald C.; Olson, Gary L. Design, synthesis, and evaluation of a pyrrolinone-peptide hybrid ligand for the class II MHC protein HLA-DR1. Journal of the American Chemical Society (1998), 120(48), 12704-12705.

364

Gidalevitz, David; Mindyuk, Oksana Y.; Stetzer, MacKenzie R.; Heiney, Paul A.; Kurnaz, M. Levent; Schwartz, Daniel K.; Ocko, Benjamin M.; McCauley, John P., Jr.; Smith, Amos B., III. A Conformational Phase Transition in a Langmuir Film of an Amphiphilic Azacrown. Journal of Physical Chemistry B (1998), 102(35), 6688-6691.

363

Smith, Amos B., III; Friestad, Gregory K.; Duan, James J.-W.; Barbosa, Joseph; Hull, Kenneth G.; Iwashima, Makoto; Qiu, Yuping; Spoors, P. Grant; Bertounesque, Emmanuel; Salvatore, Brian A. Total Synthesis of (+)-Calyculin A and (-)-Calyculin B. Journal of Organic Chemistry (1998), 63(22), 7596-7597.

362

Arimoto, Hirokazu; Kaufman, Michael D.; Kobayashi, Kaoru; Qiu, Yuping; Smith, Amos B., III. Anomalous epoxide formation upon Wittig olefination with 1-iodoethyl triphenylphosphonium ylide. Synlett (1998), (7), 765-767.

361

Khong, Anthony; Jimenez-Vazquez, Hugo A.; Saunders, Martin; Cross, R. James; Laskin, Julia; Peres, Tikva; Lifshitz, Chava; Strongin, Rob; Smith, Amos B., III. An NMR Study of He2 Inside C70. Journal of the American Chemical Society (1998), 120(25), 6380-6383.

360

Hirschmann, Ralph; Yao, Wenqing; Arison, Byron; Maechler, Laurie; Rosegay, Avery; Sprengeler, Paul A.; Smith, Amos B., III. Synthesis of the first tricyclic homodetic peptide. use of coordinated orthogonal deprotection to achieve directed ring closure. Tetrahedron (1998), 54(25), 7179-7202.

359

Smith, Amos B., III; Ott, Gregory R. Total Syntheses of (-)-Macrolactin A, (+)-Macrolactin E, and (-)-Macrolactinic Acid: An Exercise in Stille Cross-Coupling Chemistry. Journal of the American Chemical Society (1998), 120(16), 3935-3948.

358

Hirschmann, Ralph; Hynes, John, Jr.; Cichy-Knight, Maria A.; van Rijn, Rachel D.; Sprengeler, Paul A.; Spoors, P. Grant; Shakespeare, William C.; Pietranico-Cole, Sherrie; Barbosa, Joseph; Liu, Josephine; Yao, Wenqing; Rohrer, Susan; Smith, Amos B., III. Modulation of Receptor and Receptor Subtype Affinities Using Diastereomeric and Enantiomeric Monosaccharide Scaffolds as a Means to Structural and Biological Diversity. A New Route to Ether Synthesis. Journal of Medicinal Chemistry (1998), 41(9), 1382-1391.

357

Smith, Amos B., III; Barbosa, Joseph. (+)-Thiazinotrienomycin E: relative and absolute stereochemistry. Tetrahedron Letters (1998), 39(19), 2891-2894.

356

Sudoh, Masao; Pauletti, Giovanni M.; Yao, Wenqing; Moser, William; Yokoyama, Akihisa; Pasternak, Alexander; Sprengeler, Paul A.; Smith, Amos B., III; Hirschmann, Ralph; Borchardt, Ronald T. Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers. Pharmaceutical Research (1998), 15(5), 719-725.

355

Smith, Amos B.; Lin, Qiyan. Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains. Bioorganic & Medicinal Chemistry Letters (1998), 8(6), 567-568.

354

Smith, Amos B., III; Condon, Stephen M.; McCauley, John A. Total Synthesis of Immunosuppressants: Unified Strategies Exploiting Dithiane Couplings and s-Bond Olefin Constructions. Accounts of Chemical Research (1998), 31(1), 35-46.

353

A.B. Smith, III. Organic Syntheses, John Wiley & Son, Inc.: New York, 1997; Vol. 50.

352

Smith, Amos B., III; Chen, Sean S.-Y.; Nelson, Frances C.; Reichert, Janice M.; Salvatore, Brian A. Total Syntheses of (+)-Acutiphycin and (+)-trans-20,21-Didehydroacutiphycin. Journal of the American Chemical Society (1997), 119(45), 10935-10946.

351

Gidalevitz, David; Mindyuk, Oksana Y.; Heiney, Paul A.; Ocko, Benjamin M.; Henderson, Philippe; Ringsdorf, Helmut; Boden, Neville; Bushby, Richard J.; Martin, Philip S.; Strzalka, Joseph; McCauley, John P., Jr.; Smith, Amos B., III. Structure of Discotic Liquid Crystalline Compounds at the Air-Water Interface. Journal of Physical Chemistry B (1997), 101(50), 10870-10875.

350

Smith, Amos B., III; Lin, Qiyan; Nakayama, Kiyoshi; Boldi, Armen M.; Brook, Christopher S.; Mcbriar, Mark D.; Moser, William H.; Sobukawa, Masao; Zhuang, Linghang. Spongistatin synthetic studies. 3. Construction of the C(1-17) spiroketal. Tetrahedron Letters (1997), 38(50), 8675-8678.

349

Smith, Amos B., III; Zhuang, Linghang; Brook, Christopher S.; Lin, Qiyan; Moser, William H.; Trout, Robert E. Lee; Boldi, Armen M. Spongistatin synthetic studies. 2. Assembly of the C(18-28) spiroketal. Tetrahedron Letters (1997), 38(50), 8671-8674.

348

Smith, Amos B., III; Zhuang, Linghang; Brook, Christopher S.; Boldi, Armen M.; Mcbriar, Mark D.; Moser, William H.; Murase, Noriaki; Nakayama, Kiyoshi; Verhoest, Patrick R.; Lin, Qiyan. Spongistatin synthetic studies. 1. Construction of a C(29-48) subtarget. Tetrahedron Letters (1997), 38(50), 8667-8670.

347

Sunazuka, Toshiaki; Hirose, Tomoyasu; Harigaya, Yoshihiro; Takamatsu, Satoshi; Hayashi, Masahiko; Komiyama, Kanki; Omura, Satoshi; Sprengeler, Paul A.; Smith, Amos B., III. Relative and Absolute Stereochemistries and Total Synthesis of (+)-Macrosphelides A and B, Potent, Orally Bioavailable Inhibitors of Cell-Cell Adhesion. Journal of the American Chemical Society (1997), 119(42), 10247-10248.

346

K.Chen, C.S. Brook, and A.B. Smith, III. 6-7-Dihydrocyclopenta-1,3-dioxin-5(4H)-one. Org. Syn. 1997, 75, 189-194

345

A.B. Smith, III, K.M. Yager, B.W. Phillips, and C.M. Taylor. Enantiospecific Synthesis of Diethyl (R)-(-)-(1-Amino-3-methylbutyl) Phosphonate. Org. Syn. 1997, 75, 19-30

344

Hirschmann, Ralph; Yager, Kraig M.; Taylor, Carol M.; Witherington, Jason; Sprengeler, Paul A.; Phillips, Barton W.; Moore, William; Smith, Amos B., III. Phosphonate Diester and Phosphonamide Synthesis. Reaction Coordinate Analysis by 31P NMR Spectroscopy: Identification of Pyrophosphonate Anhydrides and Highly Reactive Phosphonylammonium Salts. Journal of the American Chemical Society (1997), 119(35), 8177-8190.

343

Obata, Rika; Sunazuka, Toshiaki; Tian, Zhiming; Tomoda, Hiroshi; Harigaya, Yoshihiro; Omura, Satoshi; Smith, Amos B., III. New analogs of the pyripyropene family of ACAT inhibitors via a-pyrone fragmentation and g-acylation/cyclization. Chemistry Letters (1997), (9), 935-936.

342

Smith, Amos B., III; Hartz, Richard A.; Spoors, P. Grant; Rainier, Jon D. Tremorgenic indole alkaloids. 10. An improved asymmetric synthesis of a tricyclic common intermediate. Israel Journal of Chemistry (1997), 37(1), 69-80.

341

Smith, Amos B., III; Hirschmann, Ralph; Pasternak, Alexander; Yao, Wenquing; Sprengeler, Paul A.; Holloway, M. Katharine; Kuo, Lawrence C.; Chen, Zhongguo; Darke, Paul L.; Schleif, William A. An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex. Journal of Medicinal Chemistry (1997), 40(16), 2440-2444.

340

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